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Biomed Chromatogr

Title:		Identification of metabolic markers in patients with type 2 Diabetes by Ultrafast gas chromatography coupled to electronic nose. A pilot study
Author(s):		Mendez-Rodriguez KB; Figueroa-Vega N; Ilizaliturri-Hernandez CA; Cardona-Alvarado M; Borjas-Garcia JA; Kornhauser C; Malacara JM; Flores-Ramirez R; Perez-Vazquez FJ;
Address:		"Coordinacion para la Innovacion y Aplicacion de la Ciencia y la Tecnologia (CIACyT), Universidad Autonoma de San Luis Potosi, San Luis Potosi, S.L.P., Mexico. Department of Medical Sciences, University of Guanajuato, Leon, Gto., Mexico. Department of Nephrology, Hospital Central Dr. Ignacio Morones Prieto, San Luis Potosi, S.L.P., Mexico. CONACYT Research Fellow, Coordinacion para la Innovacion y Aplicacion de la Ciencia y la Tecnologia (CIACYT), Universidad Autonoma de San Luis Potosi, San Luis Potosi, S.L.P., Mexico"
Journal Title:		Biomed Chromatogr
Year:		2020
Volume:		20200813
Issue:		12
Page Number:		e4956 -
DOI:		10.1002/bmc.4956
ISSN/ISBN:		1099-0801 (Electronic) 0269-3879 (Linking)
Abstract:		"Metabolomics is a potential tool for the discovery of new biomarkers in the early diagnosis of diseases. An ultra-fast gas chromatography system equipped to an electronic nose detector (FGC eNose) was used to identify the metabolomic profile of Volatile Organic Compounds (VOCs) in type 2 diabetes (T2D) urine from Mexican population. A cross-sectional, comparative, and clinical study with translational approach was performed. We recruited twenty T2D patients and twenty-one healthy subjects. Urine samples were taken and analyzed by FGC eNose. Eighty-eight compounds were identified through Kovats's indexes. A natural variation of 30% between the metabolites, expressed by study groups, was observed in Principal Component 1 and 2 with a significant difference (p < 0.001). The model, performed through a Canonical Analysis of Principal coordinated (CAP), allowed a correct classification of 84.6% between healthy and T2D patients, with a 15.4% error. The metabolites 2-propenal, 2-propanol, butane- 2,3-dione and 2-methylpropanal, were increased in patients with T2D, and they were strongly correlated with discrimination between clinically healthy people and T2D patients. This study identified metabolites in urine through FGC eNose that can be used as biomarkers in the identification of T2D patients. However, more studies are needed for its implementation in clinical practice"
Keywords:		"Adult Aged Biomarkers/urine Chromatography, Gas/*methods Cross-Sectional Studies Diabetes Mellitus, Type 2/*metabolism *Electronic Nose Humans Metabolomics/*methods Middle Aged Pilot Projects Volatile Organic Compounds/*urine T2d electronic nose gas chrom;"
Notes:		"MedlineMendez-Rodriguez, Karen Beatriz Figueroa-Vega, Nicte Ilizaliturri-Hernandez, Cesar Arturo Cardona-Alvarado, Monica Borjas-Garcia, Jaime Antonio Kornhauser, Carlos Malacara, Juan Manuel Flores-Ramirez, Rogelio Perez-Vazquez, Francisco Javier eng FOSEC SS/IMSS/ISSSTE A3-S38681/Consejo Nacional de Ciencia y Tecnologia/ FAI-UASLP-2019-C19-FAI-05-73.73/Universidad Autonoma de San Luis Potosi/ DAIP-UG (60/2018, to NF-V)/Universidad de Guanajuato/ England 2020/07/25 Biomed Chromatogr. 2020 Dec; 34(12):e4956. doi: 10.1002/bmc.4956. Epub 2020 Aug 13"