| Title: | The Malaria Metabolite HMBPP Does Not Trigger Erythrocyte Terpene Release |
| Address: | "Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, United States. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States. Department of Pediatrics, Division of Infectious Diseases, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States" |
| DOI: | 10.1021/acsinfecdis.0c00548 |
| ISSN/ISBN: | 2373-8227 (Electronic) 2373-8227 (Linking) |
| Abstract: | "Infection with malarial parasites renders hosts more mosquito-attractive than their uninfected, healthy counterparts. One volatile organic compound, alpha-pinene, is associated with Plasmodium spp. infection in multiple studies and is a known mosquito attractant. However, how malarial infection results in elevated levels of host-associated alpha-pinene remains unclear. One study suggested that exposure of erythrocytes to the malarial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) results in increased levels of alpha-pinene. Here we establish that endogenous levels of alpha-pinene are present in human erythrocytes, that these levels vary widely by erythrocyte donor, and that alpha-pinene levels are not altered by HMBPP treatment" |
| Keywords: | Animals Erythrocytes Humans *Malaria Terpenes *Volatile Organic Compounds Plasmodium falciparum malaria semiochemical volatile organic compound alpha-pinene; |
| Notes: | "MedlineMiller, Justin J Odom John, Audrey R eng R21 AI144472/AI/NIAID NIH HHS/ R21 AI130584/AI/NIAID NIH HHS/ R21 AI154370/AI/NIAID NIH HHS/ R21 AI123808/AI/NIAID NIH HHS/ R01 AI103280/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2020/09/24 ACS Infect Dis. 2020 Oct 9; 6(10):2567-2572. doi: 10.1021/acsinfecdis.0c00548. Epub 2020 Sep 29" |
