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Environ Res
Title: | "Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction" |
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Author(s): | McGraw KE; Riggs DW; Rai S; Navas-Acien A; Xie Z; Lorkiewicz P; Lynch J; Zafar N; Krishnasamy S; Taylor KC; Conklin DJ; DeFilippis AP; Srivastava S; Bhatnagar A; |
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Address: | "Christina Lee Brown Envirome Institute, 302 E Muhammad Ali Blvd, Louisville, KY, 40202, USA; Superfund Research Center, 302 E Muhammad Ali Blvd, Louisville, KY 40202, USA; University of Louisville School of Public Health and Information Sciences, USA; Department of Environmental and Occupational Health Sciences, USA. Christina Lee Brown Envirome Institute, 302 E Muhammad Ali Blvd, Louisville, KY, 40202, USA; Superfund Research Center, 302 E Muhammad Ali Blvd, Louisville, KY 40202, USA; University of Louisville School of Public Health and Information Sciences, USA; Department of Epidemiology and Population Health, USA. Christina Lee Brown Envirome Institute, 302 E Muhammad Ali Blvd, Louisville, KY, 40202, USA; Superfund Research Center, 302 E Muhammad Ali Blvd, Louisville, KY 40202, USA; University of Louisville School of Public Health and Information Sciences, USA; Department of Bioinformatics and Biostatistics, 485 E Gray Street, Louisville, KY, 40202, USA. Columbia University Mailman School of Public Health, USA; Department of Environmental Health Science, 722 W 168th St, New York, NY, 10032, USA. Christina Lee Brown Envirome Institute, 302 E Muhammad Ali Blvd, Louisville, KY, 40202, USA; Superfund Research Center, 302 E Muhammad Ali Blvd, Louisville, KY 40202, USA. Christina Lee Brown Envirome Institute, 302 E Muhammad Ali Blvd, Louisville, KY, 40202, USA. University of Louisville School of Public Health and Information Sciences, USA; Department of Epidemiology and Population Health, USA. Christina Lee Brown Envirome Institute, 302 E Muhammad Ali Blvd, Louisville, KY, 40202, USA; Superfund Research Center, 302 E Muhammad Ali Blvd, Louisville, KY 40202, USA; University of Louisville School of Public Health and Information Sciences, USA. Christina Lee Brown Envirome Institute, 302 E Muhammad Ali Blvd, Louisville, KY, 40202, USA; Superfund Research Center, 302 E Muhammad Ali Blvd, Louisville, KY 40202, USA. Electronic address: aruni@louisville.edu" |
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Journal Title: | Environ Res |
Year: | 2021 |
Volume: | 20210224 |
Issue: | |
Page Number: | 110903 - |
DOI: | 10.1016/j.envres.2021.110903 |
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ISSN/ISBN: | 1096-0953 (Electronic) 0013-9351 (Print) 0013-9351 (Linking) |
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Abstract: | "BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Exposure to air pollution, specifically particulate matter of diameter =2.5 mum (PM(2.5)), is a well-established risk factor for CVD. However, the contribution of gaseous pollutant exposure to CVD risk is less clear. OBJECTIVE: To examine the vascular effects of exposure to individual volatile organic compounds (VOCs) and mixtures of VOCs. METHODS: We measured urinary metabolites of acrolein (CEMA and 3HPMA), 1,3-butadiene (DHBMA and MHBMA3), and crotonaldehyde (HPMMA) in 346 nonsmokers with varying levels of CVD risk. On the day of enrollment, we measured blood pressure (BP), reactive hyperemia index (RHI - a measure of endothelial function), and urinary levels of catecholamines and their metabolites. We used generalized linear models for evaluating the association between individual VOC metabolites and BP, RHI, and catecholamines, and we used Bayesian Kernel Machine Regression (BKMR) to assess exposure to VOC metabolite mixtures and BP. RESULTS: We found that the levels of 3HPMA were positively associated with systolic BP (0.98 mmHg per interquartile range (IQR) of 3HPMA; CI: 0.06, 1.91; P = 0.04). Stratified analysis revealed an increased association with systolic BP in Black participants despite lower levels of urinary 3HPMA. This association was independent of PM(2.5) exposure and BP medications. BKMR analysis confirmed that 3HPMA was the major metabolite associated with higher BP in the presence of other metabolites. We also found that 3HPMA and DHBMA were associated with decreased endothelial function. For each IQR of 3HPMA or DHBMA, there was a -4.4% (CI: -7.2, -0.0; P = 0.03) and a -3.9% (CI: -9.4, -0.0; P = 0.04) difference in RHI, respectively. Although in the entire cohort the levels of several urinary VOC metabolites were weakly associated with urinary catecholamines and their metabolites, in Black participants, DHBMA levels showed strong associations with urinary norepinephrine and normetanephrine levels. DISCUSSION: Exposure to acrolein and 1,3-butadiene is associated with endothelial dysfunction and may contribute to elevated risk of hypertension in participants with increased sympathetic tone, particularly in Black individuals" |
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Keywords: | Acrolein *Air Pollutants/analysis/toxicity *Air Pollution/analysis Aldehydes Bayes Theorem Butadienes Environmental Exposure/analysis Environmental Monitoring Humans Particulate Matter/analysis/toxicity *Volatile Organic Compounds Blood pressure Cvd Cardi; |
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Notes: | "MedlineMcGraw, Katlyn E Riggs, Daniel W Rai, Shesh Navas-Acien, Ana Xie, Zhengzhi Lorkiewicz, Pawel Lynch, Jordan Zafar, Nagma Krishnasamy, Sathya Taylor, Kira C Conklin, Daniel J DeFilippis, Andrew P Srivastava, Sanjay Bhatnagar, Aruni eng P50 HL120163/HL/NHLBI NIH HHS/ R01 ES029846/ES/NIEHS NIH HHS/ P42 ES023716/ES/NIEHS NIH HHS/ P42 ES010349/ES/NIEHS NIH HHS/ T32 ES011564/ES/NIEHS NIH HHS/ P30 GM127607/GM/NIGMS NIH HHS/ R01 ES019217/ES/NIEHS NIH HHS/ R01 ES029967/ES/NIEHS NIH HHS/ R01 HL122676/HL/NHLBI NIH HHS/ P30 ES009089/ES/NIEHS NIH HHS/ U54 HL120163/HL/NHLBI NIH HHS/ R01 HL149351/HL/NHLBI NIH HHS/ Netherlands 2021/02/27 Environ Res. 2021 May; 196:110903. doi: 10.1016/j.envres.2021.110903. Epub 2021 Feb 24" |
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Citation: El-Sayed AM 2024. The Pherobase: Database of Pheromones and Semiochemicals. <http://www.pherobase.com>.
© 2003-2024 The Pherobase - Extensive Database of Pheromones and Semiochemicals. Ashraf M. El-Sayed.
Page created on 19-12-2024
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