| Title: | A multigene family encoding a diverse array of putative pheromone receptors in mammals |
| Address: | "Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA" |
| DOI: | 10.1016/s0092-8674(00)80537-1 |
| ISSN/ISBN: | 0092-8674 (Print) 0092-8674 (Linking) |
| Abstract: | "The vomeronasal organ of mammals is an olfactory sensory structure that detects pheromones. It contains two subsets of sensory neurons that differentially express G alpha(o) and G alpha(i2). By comparing gene expression in single neurons, we identified a novel multigene family that codes for a diverse array of candidate pheromone receptors (VRs) expressed by the G alpha(o)+ subset. Different VRs are expressed by different neurons, but those neurons are interspersed, suggesting a distributed mode of sensory coding. Chromosome mapping experiments suggest an evolutionary connection between genes encoding VRs and receptors for volatile odorants. However, a dramatically different structure for VRs and the existence of variant VR mRNA forms indicate that there are diverse strategies to detect functionally distinct sensory stimuli" |
| Keywords: | "Amino Acid Sequence Animals *Chemoreceptor Cells Chromosome Mapping Cloning, Molecular GTP-Binding Protein alpha Subunit, Gi2 GTP-Binding Protein alpha Subunits *GTP-Binding Protein alpha Subunits, Gi-Go GTP-Binding Proteins/metabolism Genetic Linkage *He;" |
| Notes: | "MedlineMatsunami, H Buck, L B eng Research Support, Non-U.S. Gov't 1997/08/22 Cell. 1997 Aug 22; 90(4):775-84. doi: 10.1016/s0092-8674(00)80537-1" |
