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Behav Brain Res

Title:		Intracranial androgenic activation of male-typical behaviors in house mice: motivation versus performance
Author(s):		Matochik JA; Sipos ML; Nyby JG; Barfield RJ;
Address:		"Department of Psychology, Lehigh University, Bethlehem, PA 18015"
Journal Title:		Behav Brain Res
Year:		1994
Volume:		60
Issue:		2
Page Number:		141 - 149
DOI:		10.1016/0166-4328(94)90141-4
ISSN/ISBN:		0166-4328 (Print) 0166-4328 (Linking)
Abstract:		"Castrated male mice were bilaterally implanted with 27 ga cannulae containing testosterone into either the septum, medial preoptic area (MPO), or corticomedial amygdala. One additional group of castrates received no hormone and another received only systemic testosterone via subcutaneous silastic capsules. All males were subsequently tested for ultrasonic mating vocalizations, urine marking, mounting behavior, aggression and gender preference, all of which are androgen-dependent, male-typical behaviors. In general castrates receiving no hormone performed these behaviors at low levels and animals receiving systemic testosterone performed the behaviors at normal male-typical levels. Ultrasonic vocalizations in response to female urine were activated by MPO implants. Urine marking in response to female urine appeared to be partially activated only with MPO implants. Very little mounting or fighting were seen in the brain implanted groups. Gender preference (for females over males) was restored with MPO implants and appeared to be partially activated with septal implants. The seminal vesicles of the castrates receiving brain implants were not significantly different from those receiving no hormone indicating that little or no implanted hormone was exiting the brain into general circulation. The implications of these findings for the neuroanatomy of sexual motivation and performance are discussed"
Keywords:		"Aggression/physiology Amygdala/drug effects/physiology Animals Brain/*drug effects/physiology Brain Mapping Copulation/drug effects/physiology Female Male Mice Mice, Inbred Strains *Motivation Preoptic Area/drug effects/physiology Receptors, Androgen/*dru;"
Notes:		"MedlineMatochik, J A Sipos, M L Nyby, J G Barfield, R J eng HD04484/HD/NICHD NIH HHS/ Research Support, U.S. Gov't, P.H.S. Netherlands 1994/02/28 Behav Brain Res. 1994 Feb 28; 60(2):141-9. doi: 10.1016/0166-4328(94)90141-4"