| Title: | Breath Volatile Organic Compound Profiling of Colorectal Cancer Using Selected Ion Flow-tube Mass Spectrometry |
| Author(s): | Markar SR; Chin ST; Romano A; Wiggins T; Antonowicz S; Paraskeva P; Ziprin P; Darzi A; Hanna GB; |
| Address: | "Department of Surgery and Cancer, Imperial College London, London, UK" |
| DOI: | 10.1097/SLA.0000000000002539 |
| ISSN/ISBN: | 1528-1140 (Electronic) 0003-4932 (Linking) |
| Abstract: | "OBJECTIVE: BACKGROUND:: Breath VOCs have the potential to noninvasively diagnose cancer. METHODS: Exhaled breath samples were collected using 2-L double-layered Nalophan bags, and were analyzed using selected-ion-flow-tube mass-spectrometry. Gold-standard test for comparison was endoscopy for luminal inspection and computed tomography (CT) to confirm cancer recurrence. Three studies were conducted: RESULTS:: CONCLUSION:: This study suggests the association of a single breath biomarker with the primary presence and recurrence of CRCa. Further multicenter validation studies are required to validate these findings" |
| Keywords: | "Aged Biomarkers, Tumor/analysis Breath Tests Colorectal Neoplasms/*diagnosis/metabolism Female Humans Male *Mass Spectrometry/instrumentation Neoplasm Recurrence, Local/*diagnosis/metabolism Prospective Studies Volatile Organic Compounds/*analysis/metabol;" |
| Notes: | "MedlineMarkar, Sheraz R Chin, Sung-Tong Romano, Andrea Wiggins, Tom Antonowicz, Stefan Paraskeva, Paraskevas Ziprin, Paul Darzi, Ara Hanna, George B eng DRF-2014-07-088/DH_/Department of Health/United Kingdom Research Support, Non-U.S. Gov't 2017/12/02 Ann Surg. 2019 May; 269(5):903-910. doi: 10.1097/SLA.0000000000002539" |
