| Title: | Bitter Odorants and Odorous Bitters: Toxicity and Human TAS2R Targets |
| Author(s): | Margulis E; Lang T; Tromelin A; Ziaikin E; Behrens M; Niv MY; |
| Address: | "Food Science and Nutrition, The Robert H Smith Faculty of Agriculture, Food and Environment, The Institute of Biochemistry, Food and Nutrition, The Hebrew University of Jerusalem, 76100 Rehovot, Israel. Leibniz Institute for Food Systems Biology at the Technical University of Munich, 85354 Freising, Germany. Centre des Sciences du Gout et de l'Alimentation, CNRS, INRAE, Institut Agro, Universite de Bourgogne Franche-Comte, F-21000 Dijon, France" |
| ISSN/ISBN: | 1520-5118 (Electronic) 0021-8561 (Print) 0021-8561 (Linking) |
| Abstract: | "Flavor is perceived through the olfactory, taste, and trigeminal systems, mediated by designated GPCRs and channels. Signal integration occurs mainly in the brain, but some cross-reactivities occur at the receptor level. Here, we predict potential bitterness and taste receptors targets for thousands of odorants. BitterPredict and BitterIntense classifiers suggest that 3-9% of flavor and food odorants have bitter taste, but almost none are intensely bitter. About 14% of bitter molecules are expected to have an odor. Bitterness is more common for unpleasant smells such as fishy, amine, and ammoniacal, while non-bitter odorants often have pleasant smells. Experimental toxicity values suggest that fishy ammoniac smells are more toxic than pleasant smells, regardless of bitterness. TAS2R14 is predicted as the main bitter receptor for odorants, confirmed by in vitro profiling of 10 odorants. The activity of bitter odorants may have implications for physiology due to ectopic expression of taste and smell receptors" |
| Keywords: | "Humans *Taste/physiology Odorants/analysis Taste Perception/physiology Smell *Olfactory Receptor Neurons/metabolism Receptors, G-Protein-Coupled/genetics/metabolism Gpcr Tas2r14 bitter fishy floral machine learning odor olfaction taste toxic;" |
| Notes: | "MedlineMargulis, Eitan Lang, Tatjana Tromelin, Anne Ziaikin, Evgenii Behrens, Maik Niv, Masha Y eng 2023/06/02 J Agric Food Chem. 2023 Jun 14; 71(23):9051-9061. doi: 10.1021/acs.jafc.3c00592. Epub 2023 Jun 1" |
