| Title: | Deficits in sexual and aggressive behaviors in Cnga2 mutant mice |
| Author(s): | Mandiyan VS; Coats JK; Shah NM; |
| Address: | "Neuroscience Graduate Program, Department of Anatomy, Box 2722, University of California San Francisco, San Francisco, California 94143, USA" |
| ISSN/ISBN: | 1097-6256 (Print) 1097-6256 (Linking) |
| Abstract: | "Odors detected by the vomeronasal organ or the main olfactory epithelium (MOE) trigger social behaviors in many animals. It is unknown whether MOE neurons detect cues that initiate mating or aggression. We demonstrate that mice lacking functional CNGA2 (cyclic nucleotide-gated channel alpha2), which is required for odor-evoked MOE signaling, fail to mate or fight, suggesting a broad and essential role for the MOE in regulating these behaviors" |
| Keywords: | "Aggression/*physiology Animals Cyclic Nucleotide-Gated Cation Channels Female Ion Channels/*genetics Male Mice Mice, Knockout Neurosecretory Systems/physiology Olfactory Bulb/physiology Olfactory Mucosa/*metabolism Olfactory Pathways/physiology Pheromones;neuroscience;" |
| Notes: | "MedlineMandiyan, Vidya S Coats, Jennifer K Shah, Nirao M eng R01 NS049488/NS/NINDS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2005/11/02 Nat Neurosci. 2005 Dec; 8(12):1660-2. doi: 10.1038/nn1589. Epub 2005 Oct 30" |
