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J Chromatogr A

Title:		Full evaporation headspace gas chromatography for sensitive determination of high boiling point volatile organic compounds in low boiling matrices
Author(s):		Mana Kialengila D; Wolfs K; Bugalama J; Van Schepdael A; Adams E;
Address:		"KU Leuven, Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, Herestraat 49, O&N2, PB923, B-3000 Leuven, Belgium"
Journal Title:		J Chromatogr A
Year:		2013
Volume:		20130919
Issue:
Page Number:		167 - 175
DOI:		10.1016/j.chroma.2013.09.058
ISSN/ISBN:		1873-3778 (Electronic) 0021-9673 (Linking)
Abstract:		"Determination of volatile organic components (VOC's) is often done by static headspace gas chromatography as this technique is very robust and combines easy sample preparation with good selectivity and low detection limits. This technique is used nowadays in different applications which have in common that they have a dirty matrix which would be problematic in direct injection approaches. Headspace by nature favors the most volatile compounds, avoiding the less volatile to reach the injector and column. As a consequence, determination of a high boiling solvent in a lower boiling matrix becomes challenging. Determination of VOCs like: xylenes, cumene, N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), N,N-dimethylacetamide (DMA), N-methyl-2-pyrrolidone (NMP), 1,3-dimethyl-2-imidazolidinone (DMI), benzyl alcohol (BA) and anisole in water or water soluble products are an interesting example of the arising problems. In this work, a headspace variant called full evaporation technique is worked out and validated for the mentioned solvents. Detection limits below 0.1 mug/vial are reached with RSD values below 10%. Mean recovery values ranged from 92.5 to 110%. The optimized method was applied to determine residual DMSO in a water based cell culture and DMSO and DMA in tetracycline hydrochloride (a water soluble sample)"
Keywords:		"Chromatography, Gas/*methods Linear Models Reproducibility of Results Sensitivity and Specificity Transition Temperature Volatile Organic Compounds/*analysis/chemistry Full evaporation technique Headspace-gas chromatography High boiling volatile compounds;"
Notes:		"MedlineMana Kialengila, Didi Wolfs, Kris Bugalama, John Van Schepdael, Ann Adams, Erwin eng Research Support, Non-U.S. Gov't Netherlands 2013/10/10 J Chromatogr A. 2013 Nov 8; 1315:167-75. doi: 10.1016/j.chroma.2013.09.058. Epub 2013 Sep 19"