|
Environ Int
Title: | Early life exposure to indoor air pollutants and the risk of neurodevelopmental delays: The Japan Environment and Children's Study |
|
Author(s): | Madaniyazi L; Jung CR; Fook Sheng Ng C; Seposo X; Hashizume M; Nakayama SF; Japan E; Children's Study G; |
|
Address: | "Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan; Japan Environment and Children's Study Programme Office, National Institute for Environmental Studies, Tsukuba, Japan. Japan Environment and Children's Study Programme Office, National Institute for Environmental Studies, Tsukuba, Japan; Department of Public Health, China Medical University, Taiwan. Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan. Department of Pediatric Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan; Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Japan Environment and Children's Study Programme Office, National Institute for Environmental Studies, Tsukuba, Japan. Electronic address: fabre@nies.go.jp" |
|
Journal Title: | Environ Int |
Year: | 2022 |
Volume: | 20211126 |
Issue: | |
Page Number: | 107004 - |
DOI: | 10.1016/j.envint.2021.107004 |
|
ISSN/ISBN: | 1873-6750 (Electronic) 0160-4120 (Linking) |
|
Abstract: | "Air pollution has been associated with childhood neurodevelopment. However, the role of indoor air pollution, especially volatile organic compounds (VOCs), on childhood neurodevelopment has been poorly explored to date. We investigated the association between indoor air pollutants and childhood neurodevelopment in 5,017 randomly selected children from the Japan Environment and Children's Study. When the participants reached 1.5 and 3 years of age, they were followed up with home visits and neurodevelopmental tests using the Ages and Stages Questionnaire (ASQ). At both ages, we collected indoor air samples for 1 week and measured 13 indoor air pollutants: particulate matter with an aerodynamic diameter of =2.5 mum, ozone, nitrogen dioxide, sulfur dioxide, and nine VOCs. The associations between air pollutants and ASQ scores were estimated using linear mixed effects models and weighted quantile sum regressions (WQS) at each age separately. Stratified analysis by sex was conducted. Exposure to m,p-xylene at the age of 3 was associated with lower communication, fine motor, and overall ASQ scores (coefficients: -0.18 [99% confidence intervals (CI): -0.35, -0.02], -0.23 [99 %CI: -0.43, -0.03], and - 0.72 [99 %CI: -1.41, -0.04] per 1 microg/m(3) increase, respectively). Exposure to o-xylene at the age of 3 was associated with lower communication, gross motor, fine motor, and overall ASQ scores (coefficients: -0.48 [99 %CI: -0.90, -0.07], -0.45 [99 %CI: -0.78, -0.13], -0.65 [99 %CI: -1.14, -0.16], and -2.15 [99 %CI: -3.83, -0.47] per 1 microg/m(3) increase, respectively). The WQS index was associated with lower gross motor ASQ scores at the age of 3 (coefficient: -0.27 [95 %CI: -0.51, -0.03] for one-unit WQS index increases), which was attributed to benzene (33.96%), toluene (26.02%), o-xylene (13.62%), and ethylbenzene (9.83%). Stratified analysis showed similar results. Although further investigations are required, our results suggest an association of neurodevelopmental delays with indoor low-level exposure to m,p-xylene and o-xylene in early life" |
|
Keywords: | "*Air Pollutants/analysis/toxicity *Air Pollution/analysis *Air Pollution, Indoor/adverse effects/analysis Child Humans Japan Particulate Matter/adverse effects/analysis Indoor air pollutants Neurodevelopmental delays The Japan Environment and Children's S;" |
|
Notes: | "MedlineMadaniyazi, Lina Jung, Chau-Ren Fook Sheng Ng, Chris Seposo, Xerxes Hashizume, Masahiro Nakayama, Shoji F eng Research Support, Non-U.S. Gov't Netherlands 2022/01/08 Environ Int. 2022 Jan; 158:107004. doi: 10.1016/j.envint.2021.107004. Epub 2021 Nov 26" |
|
|
|
|
|
Citation: El-Sayed AM 2024. The Pherobase: Database of Pheromones and Semiochemicals. <http://www.pherobase.com>.
© 2003-2024 The Pherobase - Extensive Database of Pheromones and Semiochemicals. Ashraf M. El-Sayed.
Page created on 19-12-2024
|