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Exp Parasitol

Title:		"Effects of alpha,beta-unsaturated lactones on larval survival and gut trypsin as well as oviposition response of Aedes aegypti"
Author(s):		Barros ME; Freitas JC; Santos GK; da Silva RC; Pontual EV; Paiva PM; Napoleao TH; Navarro DM; Menezes PH;
Address:		"Departamento de Quimica Fundamental-CCEN, Universidade Federal de Pernambuco, Av. Jornalista Anibal Fernandes, s/n - Cidade Universitaria, Recife, PE 50740-560, Brazil. Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco, Rua Dom Manuel de Medeiros, s/n - Dois Irmaos, Recife, PE 52171-900, Brazil. Departamento de Bioquimica-CCB, Universidade Federal de Pernambuco, Av. Professor Moraes Rego, s/n - Cidade Universitaria, Recife, PE 50670-420, Brazil. Departamento de Quimica Fundamental-CCEN, Universidade Federal de Pernambuco, Av. Jornalista Anibal Fernandes, s/n - Cidade Universitaria, Recife, PE 50740-560, Brazil. Electronic address: dmafn@ufpe.br"
Journal Title:		Exp Parasitol
Year:		2015
Volume:		20150601
Issue:
Page Number:		37 - 41
DOI:		10.1016/j.exppara.2015.05.017
ISSN/ISBN:		1090-2449 (Electronic) 0014-4894 (Linking)
Abstract:		"Lactones are organic cyclic esters that have been described as larvicides against Aedes aegypti and as components of oviposition pheromone of Culex quinquefasciatus. This work describes the effect of six alpha,beta-unsaturated lactones (5a-5f) on survival of A. aegypti fourth instar larvae (L4). It is also reported the effects of the lactones on L4 gut trypsin activity and oviposition behavior of A. aegypti females. Five lactones were able to kill L4 being the lactones 5a (LC50 of 39.05 ppm), 5e (LC50 of 36.30 ppm) and 5f (LC50 of 40.46 ppm) the most promising larvicides. Only the lactone 5a inhibited L4 gut trypsin activity, with an IC50 of 115.15 microg/mL. Lactones 5a, 5c, 5d and 5e did not exert deterrent or stimulatory effects on oviposition, whereas lactone 5b exhibited a strong deterrent oviposition activity. In conclusion, this work introduces new alpha,beta-unsaturated lactones as promising alternatives to control A. aegypti dissemination. The larvicidal mechanism of the lactone 5a can involve the disruption of proteolysis at larval gut"
Keywords:		Aedes/*drug effects/physiology Animals Female Inhibitory Concentration 50 Insect Vectors/*drug effects/physiology Insecticides/chemistry/*pharmacology Lactones/chemistry/*pharmacology Larva/drug effects Oviposition/*drug effects Trypsin/*drug effects/meta;
Notes:		"MedlineBarros, Maria Ester S B Freitas, Juliano C R Santos, Geanne K N da Silva, Rayane Cristine Santos Pontual, Emmanuel V Paiva, Patricia M G Napoleao, Thiago H Navarro, Daniela M A F Menezes, Paulo H eng Research Support, Non-U.S. Gov't 2015/06/06 Exp Parasitol. 2015 Sep; 156:37-41. doi: 10.1016/j.exppara.2015.05.017. Epub 2015 Jun 1"