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Environ Epigenet

Title:		Impact of mothers' early life exposure to low or high folate on progeny outcome and DNA methylation patterns
Author(s):		Ly L; Chan D; Landry M; Angle C; Martel J; Trasler J;
Address:		"Department of Human Genetics, McGill University, Montreal, QC, Canada. Research Institute of the McGill University Health Centre, Montreal, QC, Canada. Department of Pharmacology & Therapeutics, McGill University, Montreal, QC, Canada. Department of Pediatrics, McGill University, Montreal, QC, Canada"
Journal Title:		Environ Epigenet
Year:		2020
Volume:		20201118
Issue:		1
Page Number:		dvaa018 -
DOI:		10.1093/eep/dvaa018
ISSN/ISBN:		2058-5888 (Electronic) 2058-5888 (Linking)
Abstract:		"The dynamic patterning of DNA and histone methylation during oocyte development presents a potentially susceptible time for epigenetic disruption due to early life environmental exposure of future mothers. We investigated whether maternal exposure to folic acid deficient and supplemented diets starting in utero could affect oocytes and cause adverse developmental and epigenetic effects in next generation progeny. Female BALB/c mice (F0) were placed on one of four amino acid defined diets for 4 weeks before pregnancy and throughout gestation and lactation: folic acid control (rodent recommended daily intake; Ctrl), 7-fold folic acid deficient, 10-fold folic acid supplemented or 20-fold folic acid supplemented diets. F1 female pups were weaned onto Ctrl diets, mated to produce the F2 generation and the F2 offspring were examined at E18.5 for developmental and epigenetic abnormalities. Resorption rates were increased and litter sizes decreased amongst F2 E18.5-day litters in the 20-fold folic acid supplemented group. Increases in abnormal embryo outcomes were observed in all three folic acid deficient and supplemented groups. Subtle genome-wide DNA methylation alterations were found in the placentas and brains of F2 offspring in the 7-fold folic acid deficient , 10-fold folic acid supplemented and 20-fold folic acid supplemented groups; in contrast, global and imprinted gene methylation were not affected. The findings show that early life female environmental exposures to both low and high folate prior to oocyte maturation can compromise oocyte quality, adversely affecting offspring of the next generation, in part by altering DNA methylation patterns"
Keywords:		DNA methylation DOHaD developmental programming epigenetics folic acid histone methylation intergenerational effects maternal effects oocyte;
Notes:		"PubMed-not-MEDLINELy, Lundi Chan, Donovan Landry, Mylene Angle, Camille Martel, Josee Trasler, Jacquetta eng England 2020/11/27 Environ Epigenet. 2020 Nov 18; 6(1):dvaa018. doi: 10.1093/eep/dvaa018. eCollection 2020"