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Insect Biochem Mol Biol

Title:		Honeybee queen mandibular pheromone induces a starvation response in Drosophila melanogaster
Author(s):		Lovegrove MR; Dearden PK; Duncan EJ;
Address:		"Genomics Aotearoa and Biochemistry Department, University of Otago, P.O. Box 56, Dunedin, Aotearoa, New Zealand; School of Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK. Genomics Aotearoa and Biochemistry Department, University of Otago, P.O. Box 56, Dunedin, Aotearoa, New Zealand. Electronic address: peter.dearden@otago.ac.nz. School of Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: e.j.duncan@leeds.ac.uk"
Journal Title:		Insect Biochem Mol Biol
Year:		2023
Volume:		20230116
Issue:
Page Number:		103908 -
DOI:		10.1016/j.ibmb.2023.103908
ISSN/ISBN:		1879-0240 (Electronic) 0965-1748 (Linking)
Abstract:		"Eusocial insect societies are defined by the reproductive division of labour, a social structure that is generally enforced by the reproductive dominant(s) or 'queen(s)'. Reproductive dominance is maintained through behavioural dominance or production of queen pheromones, or a mixture of both. Queen mandibular pheromone (QMP) is a queen pheromone produced by queen honeybees (Apis mellifera) which represses reproduction in worker honeybees. How QMP acts to repress worker reproduction, the mechanisms by which this repression is induced, and how it has evolved this activity, remain poorly understood. Surprisingly, QMP is capable of repressing reproduction in non-target arthropods. Here we show that in Drosophila melanogaster QMP treatment mimics the starvation response, disrupting reproduction. QMP exposure induces an increase in food consumption and activation of checkpoints in the ovary that reduce fecundity and depresses insulin signalling. The magnitude of these effects is indistinguishable between QMP-treated and starved individuals. As QMP triggers a starvation response in an insect diverged from honeybees, we propose that QMP originally evolved by co-opting nutrition signalling pathways to regulate reproduction"
Keywords:		Female Bees Animals *Drosophila melanogaster *Pheromones/chemistry Social Behavior Ovary/physiology Reproduction/physiology Drosophila Eusociality Honey bee Nutrient sensing Queen mandibular pheromone;
Notes:		"MedlineLovegrove, Mackenzie R Dearden, Peter K Duncan, Elizabeth J eng Research Support, Non-U.S. Gov't England 2023/01/20 Insect Biochem Mol Biol. 2023 Mar; 154:103908. doi: 10.1016/j.ibmb.2023.103908. Epub 2023 Jan 16"