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Elife

Title:		Cytoplasmic retention and degradation of a mitotic inducer enable plant infection by a pathogenic fungus
Author(s):		Bardetti P; Castanheira SM; Valerius O; Braus GH; Perez-Martin J;
Address:		"Instituto de Biologia Funcional y Genomica (CSIC), Salamanca, Spain. Department of Molecular Microbiology and Genetics, Institute for Microbiology and Genetics, Georg-August-University, Gottingen, Germany"
Journal Title:		Elife
Year:		2019
Volume:		20191017
Issue:
Page Number:		-
DOI:		10.7554/eLife.48943
ISSN/ISBN:		2050-084X (Electronic) 2050-084X (Linking)
Abstract:		"In the fungus Ustilago maydis, sexual pheromones elicit mating resulting in an infective filament able to infect corn plants. Along this process a G2 cell cycle arrest is mandatory. Such as cell cycle arrest is initiated upon the pheromone recognition in each mating partner, and sustained once cell fusion occurred until the fungus enter the plant tissue. We describe that the initial cell cycle arrest resulted from inhibition of the nuclear transport of the mitotic inducer Cdc25 by targeting its importin, Kap123. Near cell fusion to take place, the increase on pheromone signaling promotes Cdc25 degradation, which seems to be important to ensure the maintenance of the G2 cell cycle arrest to lead the formation of the infective filament. This way, premating cell cycle arrest is linked to the subsequent steps required for establishment of the infection. Disabling this connection resulted in the inability of fungal cells to infect plants"
Keywords:		"Active Transport, Cell Nucleus Cell Fusion Fungal Proteins/*genetics/metabolism G2 Phase Cell Cycle Checkpoints/*genetics *Gene Expression Regulation, Fungal Genes, Mating Type, Fungal Genes, Reporter Green Fluorescent Proteins/genetics/metabolism Lumines;"
Notes:		"MedlineBardetti, Paola Castanheira, Sonia Marisa Valerius, Oliver Braus, Gerhard H Perez-Martin, Jose eng Marie Curie ITN Grant (FUNGIBRAIN FP7-PEOPLE-2013-ITN-607963)/European Commission/International Marie Curie ITN Grant (ARIADNE PITN-GA-2009-237936)/European Commission/International BIO2014-55398-R/Spanish Government/International BIO2017-88938-R/Spanish Government/International FUNGIBRAIN FP7-PEOPLE-2013-ITN-607963/Marie Curie ITN Grant/International ARIADNE PITN-GA-2009-237936/Marie Curie ITN Grant/International Research Support, Non-U.S. Gov't England 2019/10/18 Elife. 2019 Oct 17; 8:e48943. doi: 10.7554/eLife.48943"