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J Neurosci

Title:		Odors detected by mice deficient in cyclic nucleotide-gated channel subunit A2 stimulate the main olfactory system
Author(s):		Lin W; Arellano J; Slotnick B; Restrepo D;
Address:		"Department of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA"
Journal Title:		J Neurosci
Year:		2004
Volume:		24
Issue:		14
Page Number:		3703 - 3710
DOI:		10.1523/JNEUROSCI.0188-04.2004
ISSN/ISBN:		1529-2401 (Electronic) 0270-6474 (Print) 0270-6474 (Linking)
Abstract:		"It is believed that odor transduction in the mammalian main olfactory system only involves the cAMP-signaling pathway. Here, we report on odor responsiveness in mice with a disrupted cyclic nucleotide-gated (CNG) channel subunit A2. Several odorants, including putative pheromones, can be detected and discriminated by these mice behaviorally. These odors elicit responses in the olfactory epithelium, main olfactory bulb, and olfactory (piriform) cortex of CNGA2 knock-out mice. In addition, responses to odors detected by CNGA2 knock-out mice are relatively insensitive to inhibitors of the cAMP pathway. These results provide strong evidence that cAMP-independent pathways in the main olfactory system of mammals participate in detecting a subset of odors"
Keywords:		"Animals Behavior, Animal/drug effects/physiology Conditioning, Operant Cyclic AMP/antagonists & inhibitors/metabolism Cyclic Nucleotide-Gated Cation Channels Discrimination Learning/drug effects/physiology Dose-Response Relationship, Drug Ion Channels/def;neuroscience;"
Notes:		"MedlineLin, Weihong Arellano, Julie Slotnick, Burton Restrepo, Diego eng F32 DC000443/DC/NIDCD NIH HHS/ DC00566/DC/NIDCD NIH HHS/ DC006070/DC/NIDCD NIH HHS/ DC04657/DC/NIDCD NIH HHS/ R01 DC000566/DC/NIDCD NIH HHS/ DC0043/DC/NIDCD NIH HHS/ F32 DC000443-02/DC/NIDCD NIH HHS/ F32 DC000443-03/DC/NIDCD NIH HHS/ R01 DC006070/DC/NIDCD NIH HHS/ P30 DC004657/DC/NIDCD NIH HHS/ MH6118/MH/NIMH NIH HHS/ F32 DC000443-01/DC/NIDCD NIH HHS/ Research Support, U.S. Gov't, P.H.S. 2004/04/09 J Neurosci. 2004 Apr 7; 24(14):3703-10. doi: 10.1523/JNEUROSCI.0188-04.2004"