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Neuron

Title:		Hormonal Modulation of Pheromone Detection Enhances Male Courtship Success
Author(s):		Lin HH; Cao DS; Sethi S; Zeng Z; Chin JSR; Chakraborty TS; Shepherd AK; Nguyen CA; Yew JY; Su CY; Wang JW;
Address:		"Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA. Temasek Life Sciences Laboratory, 1 Research Link, Singapore 117604, Singapore; Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore. Pacific Biosciences Research Center, University of Hawai'i at Manoa, 1993 East-West Road, Honolulu, HI 96822, USA. Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: c8su@ucsd.edu. Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: jw800@ucsd.edu"
Journal Title:		Neuron
Year:		2016
Volume:		20160602
Issue:		6
Page Number:		1272 - 1285
DOI:		10.1016/j.neuron.2016.05.004
ISSN/ISBN:		1097-4199 (Electronic) 0896-6273 (Print) 0896-6273 (Linking)
Abstract:		"During the lifespans of most animals, reproductive maturity and mating activity are highly coordinated. In Drosophila melanogaster, for instance, male fertility increases with age, and older males are known to have a copulation advantage over young ones. The molecular and neural basis of this age-related disparity in mating behavior is unknown. Here, we show that the Or47b odorant receptor is required for the copulation advantage of older males. Notably, the sensitivity of Or47b neurons to a stimulatory pheromone, palmitoleic acid, is low in young males but high in older ones, which accounts for older males' higher courtship intensity. Mechanistically, this age-related sensitization of Or47b neurons requires a reproductive hormone, juvenile hormone, as well as its binding protein Methoprene-tolerant in Or47b neurons. Together, our study identifies a direct neural substrate for juvenile hormone that permits coordination of courtship activity with reproductive maturity to maximize male reproductive fitness"
Keywords:		"Age Factors Animals Basic Helix-Loop-Helix Transcription Factors/genetics/*physiology Copulation/drug effects/physiology *Courtship Drosophila Proteins/genetics/*physiology Drosophila melanogaster/drug effects/*physiology Fatty Acids, Monounsaturated/phar;"
Notes:		"MedlineLin, Hui-Hao Cao, De-Shou Sethi, Sachin Zeng, Zheng Chin, Jacqueline S R Chakraborty, Tuhin Subhra Shepherd, Andrew K Nguyen, Christine A Yew, Joanne Y Su, Chih-Ying Wang, Jing W eng R01 DC009597/DC/NIDCD NIH HHS/ R01 DK092640/DK/NIDDK NIH HHS/ 2016/06/07 Neuron. 2016 Jun 15; 90(6):1272-1285. doi: 10.1016/j.neuron.2016.05.004. Epub 2016 Jun 2"