| Title: | Emerging strategies for the noninvasive diagnosis of nosocomial pneumonia |
| Author(s): | Liapikou A; Cilloniz C; Torres A; |
| Address: | "a 6th Respiratory Department , Sotiria Chest Diseases Hospital , Athens , Greece. b Servei de Pneumologia , Institut Clinic del Torax, Hospital Clinic, Barcelona, IDIBAPS, CIBER Enfermedades Respiratorias, University of Barcelona , Barcelona , Spain" |
| Journal Title: | Expert Rev Anti Infect Ther |
| DOI: | 10.1080/14787210.2019.1635010 |
| ISSN/ISBN: | 1744-8336 (Electronic) 1478-7210 (Print) 1478-7210 (Linking) |
| Abstract: | "Introduction: Hospital-acquired pneumonia is a common and therapeutically challenging diagnosis that can lead to severe sepsis, critical illness, and respiratory failure. In this review, we focus on efforts to enhance microbiological diagnosis of hospital-acquired pneumonia, including ventilator-associated pneumonia. Areas covered: A systematic literature review was conducted by searching Medline from inception to December 2018, including hand-searching of the reference lists for additional studies. The search strategy comprised the following common search terms: hospital pneumonia OR nosocomial pneumonia OR noninvasive OR molecular diagnostic tests (OR point-of-care systems OR VOC [i.e. volatile organic compounds]) OR rapid (or simple or quick test), including brand names for the most common commercial tests. Expert opinion: In recent years, the microbiological diagnosis of respiratory pathogens has improved significantly by the development and implementation of molecular diagnostic tests for pneumonia. Real-time polymerase chain reaction, hybridization, and mass spectrometry-based platforms dominate the scene, with microarray-based assays, multiplex polymerase chain reaction, and MALDI-TOF mass spectrometry capable of detecting the determinants of antimicrobial resistance (mainly beta-lactamase genes). Introducing these assays into routine clinical practice for rapid identification of the causative microbes and their resistance patterns could transform the care of pneumonia, improving antimicrobial selection, de-escalation, and stewardship" |
| Keywords: | "Anti-Bacterial Agents/administration & dosage Cross Infection/*diagnosis/microbiology Humans Molecular Diagnostic Techniques/methods Pneumonia/*diagnosis/microbiology Pneumonia, Ventilator-Associated/*diagnosis/microbiology Nosocomial pneumonia Voc diagno;" |
| Notes: | "MedlineLiapikou, Adamantia Cilloniz, Catia Torres, Antoni eng Research Support, Non-U.S. Gov't Systematic Review England 2019/06/27 Expert Rev Anti Infect Ther. 2019 Jul; 17(7):523-533. doi: 10.1080/14787210.2019.1635010. Epub 2019 Jun 25" |
