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Anal Chem

Title:		Highly Integrated muGC Based on a Multisensing Progressive Cellular Architecture with a Valveless Sample Inlet
Author(s):		Liao W; Winship D; Lara-Ibeas I; Zhao X; Xu Q; Lu HT; Qian T; Gordenker R; Qin Y; Gianchandani YB;
Address:		"Department of Electrical Engineering and Computer Science, Center for Wireless Integrated MicroSensing and Systems (WIMS2), University of Michigan, Ann Arbor, Michigan 48109, United States. Department of Integrative Systems + Design, Center for Wireless Integrated MicroSensing and Systems (WIMS2), University of Michigan, Ann Arbor, Michigan 48109, United States. Department of Mechanical Engineering, Center for Wireless Integrated MicroSensing and Systems (WIMS2), University of Michigan, Ann Arbor, Michigan 48109, United States. Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, Michigan 48109, United States"
Journal Title:		Anal Chem
Year:		2023
Volume:		20230113
Issue:		4
Page Number:		2157 - 2167
DOI:		10.1021/acs.analchem.2c01818
ISSN/ISBN:		1520-6882 (Electronic) 0003-2700 (Linking)
Abstract:		"Microscale gas chromatographs (muGCs) promise in-field analysis of volatile organic compounds (VOCs) in environmental and industrial monitoring, healthcare, and homeland security applications. As a step toward addressing challenges with performance and manufacturability, this study reports a highly integrated monolithic chip implementing a multisensing progressive cellular architecture. This architecture incorporates three muGC cells that are customized for different ranges of analyte volatility; each cell includes a preconcentrator and separation column, two complementary capacitive detectors, and a photoionization detector (PID). An on-chip carrier gas filter scrubs ambient air for the analysis. The monolithic chip, with all 16 components, is 40.3 x 55.7 mm(2) in footprint. To accommodate surface adsorptive and low-volatility analytes, the architecture eliminates the commonly used inlet valve, eliminating the need for chemically inactive surfaces in the valves and pumps, allowing the use of standard parts. Representative analysis is demonstrated from a nonpolar 14-analyte mixture, a polar 12-analyte mixture, and a 3-phosphonate ester mixture, covering a wide vapor pressure range (0.005-68.5 kPa) and dielectric constant range (1.8-23.2). The three types of detectors show highly complementary responses. Quantitative analysis is shown in the tens to hundreds ppb range. With 200 mL samples, the projected detection limits reach 0.12-4.7 ppb. Limited tests performed at 80% humidity showed that the analytes with vapor pressures <12 kPa were unaffected. A typical full run takes 28 min and consumes 2.3 kJ energy for the fluidic elements (excluding electronics). By eliminating chip-to-chip fluidic interconnections and requiring just one custom-fabricated element, this work presents a path toward high-performance and highly manufacturable muGCs"
Keywords:
Notes:		"PubMed-not-MEDLINELiao, Weilin Winship, Declan Lara-Ibeas, Irene Zhao, Xiangyu Xu, Qu Lu, Hsueh-Tsung Qian, Tao Gordenker, Robert Qin, Yutao Gianchandani, Yogesh B eng 2023/01/14 Anal Chem. 2023 Jan 31; 95(4):2157-2167. doi: 10.1021/acs.analchem.2c01818. Epub 2023 Jan 13"