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Sheng Wu Gong Cheng Xue Bao

Title:		[Biomarkers for early screening and diagnosis of breast cancer: a review]
Author(s):		Liang Y; Hao M; Guo R; Li X; Li Y; Yu C; Yang Z;
Address:		"Innovation Center of Molecular Diagnostics, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production and Construction Corps, College of Life Science and Technology, Tarim University, Alar 843300, Xinjiang, China"
Journal Title:		Sheng Wu Gong Cheng Xue Bao
Year:		2023
Volume:		39
Issue:		4
Page Number:		1425 - 1444
DOI:		10.13345/j.cjb.220699
ISSN/ISBN:		1872-2075 (Electronic) 1000-3061 (Linking)
Abstract:		"The estimated new cases of breast cancer (BC) patients were 2.26 million in 2020, which accounted for 11.7% of all cancer patients, making it the most prevalent cancer worldwide. Early detection, diagnosis and treatment are crucial to reduce the mortality, and improve the prognosis of BC patients. Despite the widespread use of mammography screening as a tool for BC screening, the false positive, radiation, and overdiagnosis are still pressing issues that need to be addressed. Therefore, it is urgent to develop accessible, stable, and reliable biomarkers for non-invasive screening and diagnosis of BC. Recent studies indicated that the circulating tumor cell DNA (ctDNA), carcinoembryonic antigen (CEA), carbohydrate antigen 15-3 (CA15-3), extracellular vesicles (EV), circulating miRNAs and BRCA gene from blood, and the phospholipid, miRNAs, hypnone and hexadecane from urine, nipple aspirate fluid (NAF) and volatile organic compounds (VOCs) in exhaled gas were closely related to the early screening and diagnosis of BC. This review summarizes the advances of the above biomarkers in the early screening and diagnosis of BC"
Keywords:		"Humans Female Biomarkers, Tumor Early Detection of Cancer *Breast Neoplasms/diagnosis Prognosis *MicroRNAs/genetics biomarkers breast cancer diagnosis early screening noninvasiveness;"
Notes:		"MedlineLiang, Youfeng Hao, Mingxuan Guo, Rui Li, Xiaoning Li, Yongchao Yu, Changyuan Yang, Zhao chi English Abstract Review China 2023/05/08 Sheng Wu Gong Cheng Xue Bao. 2023 Apr 25; 39(4):1425-1444. doi: 10.13345/j.cjb.220699"