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Molecules

Title:		Antimicrobial Lemongrass Essential Oil-Copper Ferrite Cellulose Acetate Nanocapsules
Author(s):		Liakos IL; Abdellatif MH; Innocenti C; Scarpellini A; Carzino R; Brunetti V; Marras S; Brescia R; Drago F; Pompa PP;
Address:		"Smart Materials Group, Nanophysics Department, Istituto Italiano di Tecnologia (IIT), Via Morego 30, 16163 Genoa, Italy. ioannis.liakos@iit.it. Nanostructures Department, Istituto Italiano di Tecnologia (IIT), Via Morego 30, 16163 Genoa, Italy. Mohamed.Abdellatif@iit.it. INSTM-RU of Florence and Department of Chemistry, University of Florence, Via Della Lastruccia 3-13, 50019 Sesto F.no, Firenze, Italy. claudia.innocenti@unifi.it. Nanochemistry Department, Istituto Italiano di Tecnologia (IIT), Via Morego 30, 16163 Genoa, Italy. Alice.Scarpellini@iit.it. Smart Materials Group, Nanophysics Department, Istituto Italiano di Tecnologia (IIT), Via Morego 30, 16163 Genoa, Italy. Riccardo.Carzino@iit.it. Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia (IIT), Via Barsanti 1, 73010 Lecce, Italy. Virgilio.Brunetti@iit.it. Nanochemistry Department, Istituto Italiano di Tecnologia (IIT), Via Morego 30, 16163 Genoa, Italy. Sergio.Marras@iit.it. Nanochemistry Department, Istituto Italiano di Tecnologia (IIT), Via Morego 30, 16163 Genoa, Italy. Rosaria.Brescia@iit.it. Nanochemistry Department, Istituto Italiano di Tecnologia (IIT), Via Morego 30, 16163 Genoa, Italy. Filippo.Drago@iit.it. Nanobiointeractions & Nanodiagnostics, Istituto Italiano di Tecnologia (IIT), Via Morego 30, 16163 Genoa, Italy. Pierpaolo.Pompa@iit.it"
Journal Title:		Molecules
Year:		2016
Volume:		20160420
Issue:		4
Page Number:		520 -
DOI:		10.3390/molecules21040520
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"Cellulose acetate (CA) nanoparticles were combined with two antimicrobial agents, namely lemongrass (LG) essential oil and Cu-ferrite nanoparticles. The preparation method of CA nanocapsules (NCs), with the two antimicrobial agents, was based on the nanoprecipitation method using the solvent/anti-solvent technique. Several physical and chemical analyses were performed to characterize the resulting NCs and to study their formation mechanism. The size of the combined antimicrobial NCs was found to be ca. 220 nm. The presence of Cu-ferrites enhanced the attachment of LG essential oil into the CA matrix. The magnetic properties of the combined construct were weak, due to the shielding of Cu-ferrites from the polymeric matrix, making them available for drug delivery applications where spontaneous magnetization effects should be avoided. The antimicrobial properties of the NCs were significantly enhanced with respect to CA/LG only. This work opens novel routes for the development of organic/inorganic nanoparticles with exceptional antimicrobial activities"
Keywords:		"Anti-Infective Agents/chemistry/pharmacology Cellulose/*analogs & derivatives/chemistry Copper/chemistry/*pharmacology Cymbopogon/*chemistry Ferric Compounds/*chemistry Microbial Sensitivity Tests Nanocapsules/chemistry Oils, Volatile/chemistry/*pharmacol;"
Notes:		"MedlineLiakos, Ioannis L Abdellatif, Mohamed H Innocenti, Claudia Scarpellini, Alice Carzino, Riccardo Brunetti, Virgilio Marras, Sergio Brescia, Rosaria Drago, Filippo Pompa, Pier Paolo eng Switzerland 2016/04/23 Molecules. 2016 Apr 20; 21(4):520. doi: 10.3390/molecules21040520"