« Previous AbstractEffect of Pathogenic Fungal Infestation on the Berry Quality and Volatile Organic Compounds of Cabernet Sauvignon and Petit Manseng Grapes    Next AbstractEmissions of biogenic volatile organic compounds from urban green spaces in the six core districts of Beijing based on a new satellite dataset »

Environ Pollut

Title:		Effects of long-term and low-concentration exposures of benzene and formaldehyde on mortality of Drosophila melanogaster
Author(s):		Li X; Li Z; Shen H; Zhao H; Qin G; Xue J;
Address:		"College of Mechanical Engineering, Tongji University, Shanghai, 200092, China. College of Mechanical Engineering, Tongji University, Shanghai, 200092, China. Electronic address: lizh@tongji.edu.cn. Shanghai Institute of Measurement and Testing Technology, Shanghai, 201203, China"
Journal Title:		Environ Pollut
Year:		2022
Volume:		20220129
Issue:
Page Number:		118924 -
DOI:		10.1016/j.envpol.2022.118924
ISSN/ISBN:		1873-6424 (Electronic) 0269-7491 (Linking)
Abstract:		"Single-chemical thresholds cannot comprehensively evaluate the risk of chemical mixture exposure in indoor air. Moreover, a large number of researches have focused on short-term and high-concentration co-exposure scenarios related to different species, based on diverse endpoints, which hampers the application and improvement of existing risk evaluation models of chemical mixture exposures. More importantly, current risk evaluation models are not user-friendly for construction practitioners who do not have sufficient toxicological knowledge. Therefore, in this study, an inhalation experiment system and a hazard index (HI) were developed to investigate the risks associated with low-concentration and long-term inhalation exposure scenarios of formaldehyde and benzene, individually and combined, based on Drosophila melanogaster mortality. The results showed that the system exhibited good reproducibility in providing stable exposure concentrations during D. melanogaster life cycle. Furthermore, in a range of experimental concentrations, the interaction between formaldehyde and benzene was additive or synergistic, which was concentration- and ratio-dependent. This study is of great significance in harmonising and providing toxicity data under long-term and low-concentration exposure scenarios, which is beneficial for establishing a new user-friendly risk evaluation model for indoor chemical mixture exposures. It should be noted that the proposed HI value could indicate the hazard degrees of long-term inhalation exposures of formaldehyde and benzene, individually and combined, to D. melanogaster. However, the applicability of this index requires further experiments to evaluate the exposure risks of other volatile organic compounds (VOCs) to D. melanogaster"
Keywords:		"*Air Pollutants/analysis *Air Pollution, Indoor/analysis Animals Benzene/analysis/toxicity Drosophila melanogaster Formaldehyde/analysis/toxicity Reproducibility of Results *Volatile Organic Compounds/analysis/toxicity Benzene Drosophila adult Formaldehyd;"
Notes:		"MedlineLi, Xiaoying Li, Zhenhai Shen, Hao Zhao, Haishan Qin, Guojun Xue, Jingchuan eng England 2022/02/02 Environ Pollut. 2022 May 1; 300:118924. doi: 10.1016/j.envpol.2022.118924. Epub 2022 Jan 29"