« Previous Abstract"Anogenital distance as a predictor of attractiveness, litter size and sex ratio of rabbit does"    Next Abstract"Genetics of Ustilago maydis, a fungal pathogen that induces tumors in maize" »

Genes Dev

Title:		"Identification of fuz7, a Ustilago maydis MEK/MAPKK homolog required for a-locus-dependent and -independent steps in the fungal life cycle"
Author(s):		Banuett F; Herskowitz I;
Address:		"Department of Biochemistry and Biophysics, School of Medicine, University of California San Francisco 94143-0448"
Journal Title:		Genes Dev
Year:		1994
Volume:		8
Issue:		12
Page Number:		1367 - 1378
DOI:		10.1101/gad.8.12.1367
ISSN/ISBN:		0890-9369 (Print) 0890-9369 (Linking)
Abstract:		"Ustilago maydis is a plant pathogenic Basidiomycete fungus that exhibits dimorphism--it has a haploid, yeast-like phase and a dikaryotic, filamentous phase that is pathogenic. Establishment and maintenance of these two forms are controlled by two mating type loci, a and b. The a locus is thought to govern fusion of haploid cells to form a dikaryon and is also required for filamentous growth of the dikaryon. It encodes two components of a pheromone response pathway: pheromones and receptors. We report the identification of the U. maydis fuz7 gene, which codes for a putative dual specificity serine/threonine tyrosine kinase of the MAP kinase kinase (MAPKK/MEK) family, by homology with other members of the family. Analysis of mutants deleted for fuz7 shows that it participates in different facets of the life cycle: It is necessary for a-locus-dependent processes, such as conjugation tube formation, filament formation, and maintenance of filamentous growth, and for a-locus-independent processes, such as tumor induction and teliospore germination. fuz7 is the first U. maydis gene distinct from the b locus required for fungal pathogenicity. We propose that fuz7 is involved in at least two pathways, one of which responds to the pheromones coded by the a locus and the other to putative signals from the plant"
Keywords:		"Amino Acid Sequence Base Sequence Calcium-Calmodulin-Dependent Protein Kinases/*genetics Diploidy *Fungal Proteins Genes, Fungal/*genetics *Genes, Mating Type, Fungal Haploidy Mating Factor Mitogen-Activated Protein Kinase Kinases Models, Biological Molec;"
Notes:		"MedlineBanuett, F Herskowitz, I eng AI18738/AI/NIAID NIH HHS/ Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1994/06/15 Genes Dev. 1994 Jun 15; 8(12):1367-78. doi: 10.1101/gad.8.12.1367"