| Title: | Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation |
| Author(s): | Baltruschat L; Prisco L; Ranft P; Lauritzen JS; Fiala A; Bock DD; Tavosanis G; |
| Address: | "Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany. Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA. Molecular Neurobiology of Behaviour, University of Gottingen, 37077 Gottingen, Germany. Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA; Department of Neurological Sciences, University of Vermont, Burlington, VT 05405, USA. Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany; LIMES Institute, University of Bonn, 53115 Bonn, Germany. Electronic address: gaia.tavosanis@dzne.de" |
| DOI: | 10.1016/j.celrep.2021.108871 |
| Abstract: | "The formation and consolidation of memories are complex phenomena involving synaptic plasticity, microcircuit reorganization, and the formation of multiple representations within distinct circuits. To gain insight into the structural aspects of memory consolidation, we focus on the calyx of the Drosophila mushroom body. In this essential center, essential for olfactory learning, second- and third-order neurons connect through large synaptic microglomeruli, which we dissect at the electron microscopy level. Focusing on microglomeruli that respond to a specific odor, we reveal that appetitive long-term memory results in increased numbers of precisely those functional microglomeruli responding to the conditioned odor. Hindering memory consolidation by non-coincident presentation of odor and reward, by blocking protein synthesis, or by including memory mutants suppress these structural changes, revealing their tight correlation with the process of memory consolidation. Thus, olfactory long-term memory is associated with input-specific structural modifications in a high-order center of the fly brain" |
| Keywords: | "Animals Axons/drug effects/physiology Drosophila melanogaster/drug effects/*physiology/ultrastructure Memory Consolidation/drug effects/*physiology Memory, Long-Term/drug effects Mushroom Bodies/drug effects/*innervation/ultrastructure Nerve Net/drug effe;" |
| Notes: | "MedlineBaltruschat, Lothar Prisco, Luigi Ranft, Philipp Lauritzen, J Scott Fiala, Andre Bock, Davi D Tavosanis, Gaia eng RF1 MH120679/MH/NIMH NIH HHS/ Research Support, Non-U.S. Gov't 2021/03/18 Cell Rep. 2021 Mar 16; 34(11):108871. doi: 10.1016/j.celrep.2021.108871" |
