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PLoS One

Title:		Evaluation of Melia azedarach extract-loaded poly (vinyl alcohol)/pectin hydrogel for burn wound healing
Author(s):		Lee JS; Sun KH; Park Y;
Address:		"Department of Emergency Medicine, School of Medicine, Chosun University, Gwangju, Korea"
Journal Title:		PLoS One
Year:		2022
Volume:		20220623
Issue:		6
Page Number:		e0270281 -
DOI:		10.1371/journal.pone.0270281
ISSN/ISBN:		1932-6203 (Electronic) 1932-6203 (Linking)
Abstract:		"BACKGROUND: In this study, a hydrogel comprising poly (vinyl alcohol)/pectin (PVA/PET) was prepared by the addition of Melia azedarach extract for epithelial restoration. M. azedarach extract (MAE) contains volatile organic plant-derived compounds with antimicrobial properties. MAE has a variety of physiological properties, including antimicrobial, insecticidal, and anti-inflammatory activity. This study aimed to investigate whether MAE-loaded PVA/PET hydrogels have protective effects against burn wound healing. METHODS AND FINDINGS: To mix M. azedarach with the gel, nanoparticles containing M. azedarach were prepared using chitosan/maltodextrin as the wall material. A PVA/PET hydrogel containing M. azedarach was developed and its applicability as a wound dressing was evaluated. In the in vitro scratch assay, MAE treatment showed a scratch recovery-promoting effect comparable to that of the positive control TGF-beta1. The MAE-PVA/PET hydrogel was found to be non-toxic, and the antibacterial activity of the hydrogel was excellent against both gram-positive and gram-negative bacteria. Furthermore, as the formulated hydrogel demonstrated strong antimicrobial activity, its wound-healing efficacy was investigated in vivo using a rat model. CONCLUSION: MAE was found to be effective against burn wounds and to have antimicrobial activity in vitro and in vivo"
Keywords:		Animals Anti-Bacterial Agents/pharmacology/therapeutic use *Burns/drug therapy Gram-Negative Bacteria Gram-Positive Bacteria Hydrogels/pharmacology *Melia azedarach Pectins/pharmacology Polyvinyl Alcohol/pharmacology Rats Wound Healing;
Notes:		"MedlineLee, Jun Seung Sun, Kyung Hoon Park, Yongjin eng Research Support, Non-U.S. Gov't 2022/06/24 PLoS One. 2022 Jun 23; 17(6):e0270281. doi: 10.1371/journal.pone.0270281. eCollection 2022"