| Title: | The clinical effects of hospitalization in a low pollutant room on atopic dermatitis |
| Author(s): | Lee JH; Kim J; Lee SW; Suh J; Yu JS; Park E; Lee J; Kim H; Lee KS; Chang EY; Cho JB; Kim KB; Han Y; Ahn K; Lee SI; |
| Address: | "Department of Pediatrics, Gwangmyeong Sungae Hospital, Gwangmyeong 423-033, Korea" |
| DOI: | 10.5415/apallergy.2011.1.2.87 |
| ISSN/ISBN: | 2233-8268 (Electronic) 2233-8276 (Print) 2233-8276 (Linking) |
| Abstract: | "BACKGROUND: Environmental pollutants are thought to be one of major triggers of atopic dermatitis (AD). OBJECTIVE: We attempted to evaluate the clinical effects of environment with low indoor pollutant levels on AD management. METHODS: Fifty-one children (mean age 1.7 years) with moderate to severe AD who failed to show improvement with conventional management were recruited. Disease severity was assessed by SCORAD (Scoring of AD) indices. They were admitted in a low pollutant oom for 3-4 days (mean 3.3 days) which was designed to keep low levels of dust, house dust mites, micro-organisms, and indoor air pollutants such as total volatile organic compounds (TVOCs), particulate matter (PM), and so on. Air pollutant levels in the low pollutant room were lower than primary standards defined by the Korean Ministry of Environment. we compared disease severity on admission and after discharge, and the pollutant levels of each patient's home and low pollutant room. RESULTS: The SCORAD was significantly reduced from 42.0 +/- 11 .5 to 29.8 +/- 8.9 (p < 0.001) by management in a low pollutant room. PM(2.5), PM(10), formaldehyde, TVOCs, carbon dioxide, bacterial suspensions, and indoor molds were significantly higher in the patient's home than low pollutant room. Out of 29 patients who deteriorated after discharge to their home, 8 patients were admitted again, and their SCORAD was rapidly decreased from 53.1 +/- 16.2 to 39.2 +/- 9.8 (p = 0.036). CONCLUSION: Indoor air pollutants are likely to affect AD in susceptible individuals. Environmental control to lower indoor air pollutant levels might be necessary for better management of AD in some patients" |
| Keywords: | Air pollution Atopic dermatitis Childhood Environment Indoor; |
| Notes: | "PubMed-not-MEDLINELee, Jung Hyun Kim, Jihyun Lee, Sang Woon Suh, Jungmin Yu, Jung Seok Park, Eunah Lee, Jinyoung Kim, Hyunmi Lee, Kwang Shin Chang, Eun Young Cho, Joong Bum Kim, Kyo Boong Han, Youngshin Ahn, Kangmo Lee, Sang-Il eng Netherlands 2011/11/05 Asia Pac Allergy. 2011 Jul; 1(2):87-92. doi: 10.5415/apallergy.2011.1.2.87. Epub 2011 Jul 28" |
