| Title: | Fecal Microbiota Transplantation Modulates Renal Phenotype in the Humanized Mouse Model of IgA Nephropathy |
| Author(s): | Lauriero G; Abbad L; Vacca M; Celano G; Chemouny JM; Calasso M; Berthelot L; Gesualdo L; De Angelis M; Monteiro RC; |
| Address: | "Center for Research on Inflammation, Inflamex Laboratory of Excellence, Paris University, Paris, France. INSERM U1149, Paris, France. CNRS ERL8252, Paris, France. Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy. Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy" |
| DOI: | 10.3389/fimmu.2021.694787 |
| ISSN/ISBN: | 1664-3224 (Electronic) 1664-3224 (Linking) |
| Abstract: | "Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis. Several observations suggest that gut microbiota could be implicated in IgAN pathophysiology. Aiming at exploring whether microbiota modulation is able to influence disease outcome, we performed fecal microbiota transplantation (FMT) from healthy controls (HC-sbjs), non-progressor (NP-pts) and progressor (P-pts) IgAN patients to antibiotic-treated humanized IgAN mice (alpha1KI-CD89Tg), by oral gavage. FMT was able to modulate renal phenotype and inflammation. On one hand, the microbiota from P-pts was able to induce an increase of serum BAFF and galactose deficient-IgA1 levels and a decrease of CD89 cell surface expression on blood CD11b(+) cells which was associated with soluble CD89 and IgA1 mesangial deposits. On the other hand, the microbiota from HC-sbjs was able to induce a reduction of albuminuria immediately after gavage, an increased cell surface expression of CD89 on blood CD11b(+) cells and a decreased expression of KC chemokine in kidney. Higher serum BAFF levels were found in mice subjected to FMT from IgAN patients. The main bacterial phyla composition and volatile organic compounds profile significantly differed in mouse gut microbiota. Microbiota modulation by FMT influences IgAN phenotype opening new avenues for therapeutic approaches in IgAN" |
| Keywords: | "Animals Antigens, CD/genetics/metabolism B-Cell Activating Factor/blood Bacteria/*metabolism Case-Control Studies Disease Models, Animal Dysbiosis *Fecal Microbiota Transplantation *Gastrointestinal Microbiome Glomerulonephritis, IGA/immunology/metabolism;" |
| Notes: | "MedlineLauriero, Gabriella Abbad, Lilia Vacca, Mirco Celano, Giuseppe Chemouny, Jonathan M Calasso, Maria Berthelot, Laureline Gesualdo, Loreto De Angelis, Maria Monteiro, Renato C eng Research Support, Non-U.S. Gov't Switzerland 2021/10/30 Front Immunol. 2021 Oct 12; 12:694787. doi: 10.3389/fimmu.2021.694787. eCollection 2021" |
