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Eur Respir J

Title:		Exhaled breath to screen for malignant pleural mesothelioma: a validation study
Author(s):		Lamote K; Vynck M; Thas O; Van Cleemput J; Nackaerts K; van Meerbeeck JP;
Address:		"Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium kevin.lamote@ugent.be. Dept of Internal Medicine, Ghent University, Ghent, Belgium. Dept of Mathematical Modelling, Statistics and Bio-informatics, Ghent University, Ghent, Belgium. National Institute for Applied Statistics Research Australia (NIASRA), University of Wollongong, Keiraville, Australia. Occupational Health Service, Eternit N.V., Kapelle-op-den-Bos, Belgium. Dept of Respiratory Diseases, KU Leuven, University Hospitals Leuven, Leuven, Belgium. Thoracic Oncology, Multi-disciplinary Oncological Center Antwerp (MOCA), Antwerp University Hospital, Edegem, Belgium"
Journal Title:		Eur Respir J
Year:		2017
Volume:		20171221
Issue:		6
Page Number:		-
DOI:		10.1183/13993003.00919-2017
ISSN/ISBN:		1399-3003 (Electronic) 0903-1936 (Linking)
Abstract:		"Malignant pleural mesothelioma (MPM) is predominantly caused by asbestos exposure and has a poor prognosis. Breath contains volatile organic compounds (VOCs) and can be explored as an early detection tool. Previously, we used multicapillary column/ion mobility spectrometry (MCC/IMS) to discriminate between patients with MPM and asymptomatic high-risk persons with a high rate of accuracy. Here, we aim to validate these findings in different control groups.Breath and background samples were obtained from 52 patients with MPM, 52 healthy controls without asbestos exposure (HC), 59 asymptomatic former asbestos workers (AEx), 41 patients with benign asbestos-related diseases (ARD), 70 patients with benign non-asbestos-related lung diseases (BLD) and 56 patients with lung cancer (LC).After background correction, logistic lasso regression and receiver operating characteristic (ROC) analysis, the MPM group was discriminated from the HC, AEx, ARD, BLD and LC groups with 65%, 88%, 82%, 80% and 72% accuracy, respectively. Combining AEx and ARD patients resulted in 94% sensitivity and 96% negative predictive value (NPV). The most important VOCs selected were P1, P3, P7, P9, P21 and P26.We discriminated MPM patients from at-risk subjects with great accuracy. The high sensitivity and NPV allow breath analysis to be used as a screening tool for ruling out MPM"
Keywords:		Adult Aged Asbestos/adverse effects Belgium *Breath Tests Case-Control Studies Cross-Sectional Studies Exhalation Female Humans Logistic Models Lung Neoplasms/*diagnosis Male Mesothelioma/*diagnosis Middle Aged Pleural Neoplasms/*diagnosis ROC Curve Volat;
Notes:		"MedlineLamote, Kevin Vynck, Matthijs Thas, Olivier Van Cleemput, Joris Nackaerts, Kristiaan van Meerbeeck, Jan P eng Multicenter Study Research Support, Non-U.S. Gov't Validation Study England 2017/12/23 Eur Respir J. 2017 Dec 21; 50(6):1700919. doi: 10.1183/13993003.00919-2017. Print 2017 Dec"