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Talanta

Title:		A new analytical protocol for the determination of 62 endocrine-disrupting compounds in indoor air
Author(s):		Laborie S; Moreau-Guigon E; Alliot F; Desportes A; Oziol L; Chevreuil M;
Address:		"Sorbonne Universites, UPMC Univ Paris 06, CNRS, EPHE, UMR 7619 Metis, 4 Place Jussieu, 75005 Paris, France. Electronic address: stephanie.laborie@upmc.fr. Sorbonne Universites, UPMC Univ Paris 06, CNRS, EPHE, UMR 7619 Metis, 4 Place Jussieu, 75005 Paris, France. Universite Paris Sud, CNRS, AgroParisTech, UMR 8079, ESE, F-91405 Orsay, France"
Journal Title:		Talanta
Year:		2016
Volume:		20150914
Issue:
Page Number:		132 - 141
DOI:		10.1016/j.talanta.2015.09.028
ISSN/ISBN:		1873-3573 (Electronic) 0039-9140 (Linking)
Abstract:		"The objective of this study was to develop and validate a new analytical protocol for simultaneous determination of 62 semi-volatile organic compounds in both phases of indoor air. Studied compounds belong to several families: polybrominated diphenyl ethers, polychlorinated biphenyls, hexachlorobenzene, pentachlorobenzene, phthalates, polyaromatic hydrocarbons, parabens, tetrabromobisphenol A, bisphenol A, hexabromocyclododecane, triclosan, alkylphenols, alkylphenol ethoxylates, synthetic musks (galaxolide and tonalide) and pesticides (lindane and cypermethrin). A medium volume sampling system was used to collect simultaneously these endocrine-disrupting compounds (EDCs) from the gaseous and particulate phases. An accelerated solvent extraction method was optimized to obtain all EDCs in a single extract by atmospheric phase. Their extraction from the sorbents and their analysis by liquid and gas chromatography-mass spectrometry (LC/MS/MS, GC/MS and GC/MS/MS) was validated using spiked sorbents (recovery study and analytical uncertainty analysis by fully nested design). The developed protocol achieved low limits of quantification (<0.5ng m(-3)) and low uncertainty values (<5ng m(-3)) for all compounds. Once validated, the method was applied to indoor air samples from four locations (a house, an apartment, a day nursery and an office) and compared to literature to confirm its efficiency. All target EDCs were quantified in the samples and were primarily present in the gaseous phase. The major contaminants found in indoor air were, in descending order, phthalates, synthetic musks, alkylphenols and parabens"
Keywords:		"Air Pollution, Indoor/*analysis Chemistry Techniques, Analytical/*methods Chromatography, Liquid Endocrine Disruptors/*analysis/chemistry Environmental Monitoring/*methods Gas Chromatography-Mass Spectrometry Endocrine disruptors Gas chromatography Indoor;"
Notes:		"MedlineLaborie, Stephanie Moreau-Guigon, Elodie Alliot, Fabrice Desportes, Annie Oziol, Lucie Chevreuil, Marc eng Research Support, Non-U.S. Gov't Netherlands 2015/11/26 Talanta. 2016 Jan 15; 147:132-41. doi: 10.1016/j.talanta.2015.09.028. Epub 2015 Sep 14"