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Respir Physiol Neurobiol

Title:		Does acute exposure to aldehydes impair pulmonary function and structure?
Author(s):		Abreu M; Neto AC; Carvalho G; Casquillo NV; Carvalho N; Okuro R; Ribeiro GC; Machado M; Cardozo A; Silva AS; Barboza T; Vasconcellos LR; Rodrigues DA; Camilo L; Carneiro Lde A; Jandre F; Pino AV; Giannella-Neto A; Zin WA; Correa LH; Souza MN; Carvalho AR;
Address:		"Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Brazil. Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Pulmonary Engineering, Biomedical Engineering Program, Alberto Luis Coimbra Institute of Post-Graduation and Research in Engineering, Brazil. Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil. Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Brazil; Laboratory of Inflammation and Immunity, Imunology Institute, Paulo Goes Mycrobiology Institute, Brazil. Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Inflammation and Immunity, Imunology Institute, Paulo Goes Mycrobiology Institute, Brazil. Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Biomedics Instrumentation, Biomedical Engineering Program, Alberto Luis Coimbra Institute of Post-Graduation and Research in Engineering; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Laboratory of Biological Assays on Ambient Pollution, Institute of Biophysics Carlos Chagas Filho, Brazil; Laboratory of Respiration Physiology, Carlos Chagas Filho Institute of Biophysics, Brazil; Laboratory of Pulmonary Engineering, Biomedical Engineering Program, Alberto Luis Coimbra Institute of Post-Graduation and Research in Engineering, Brazil. Electronic address: acarvalho@biof.ufrj.br"
Journal Title:		Respir Physiol Neurobiol
Year:		2016
Volume:		20160414
Issue:
Page Number:		34 - 42
DOI:		10.1016/j.resp.2016.04.002
ISSN/ISBN:		1878-1519 (Electronic) 1569-9048 (Linking)
Abstract:		"Mixtures of anhydrous ethyl alcohol and gasoline substituted for pure gasoline as a fuel in many Brazilian vehicles. Consequently, the concentrations of volatile organic compounds (VOCs) such as ketones, other organic compounds, and particularly aldehydes increased in many Brazilian cities. The current study aims to investigate whether formaldehyde, acetaldehyde, or mixtures of both impair lung function, morphology, inflammatory and redox responses at environmentally relevant concentrations. For such purpose, C57BL/6 mice were exposed to either medical compressed air or to 4 different mixtures of formaldehyde and acetaldehyde. Eight hours later animals were anesthetized, paralyzed and lung mechanics and morphology, inflammatory cells and IL-1beta, KC, TNF-alpha, IL-6, CCL2, MCP-1 contents, superoxide dismutase and catalalase activities were determined. The extra pulmonary respiratory tract was also analyzed. No differences could be detected between any exposed and control groups. In conclusion, no morpho-functional alterations were detected in exposed mice in relation to the control group"
Keywords:		"Acetaldehyde/*toxicity Air Pollutants/*toxicity Air Pollution Animals Biomechanical Phenomena Female Formaldehyde/*toxicity Lung/*drug effects/pathology/physiopathology Lung Volume Measurements Male Mice, Inbred C57BL Models, Animal Nasal Mucosa/drug effe;"
Notes:		"MedlineAbreu, Mariana de Neto, Alcendino Candido Carvalho, Giovanna Casquillo, Natalia Vasconcelos Carvalho, Niedja Okuro, Renata Ribeiro, Gabriel C Motta Machado, Mariana Cardozo, Alexia Silva, Aline Santos E Barboza, Thiago Vasconcellos, Luiz Ricardo Rodrigues, Danielle Araujo Camilo, Luciana Carneiro, Leticia de A M Jandre, Frederico Pino, Alexandre V Giannella-Neto, Antonio Zin, Walter A Correa, Leonardo Holanda Travassos Souza, Marcio Nogueira de Carvalho, Alysson R eng Research Support, Non-U.S. Gov't Netherlands 2016/04/23 Respir Physiol Neurobiol. 2016 Jul 15; 229:34-42. doi: 10.1016/j.resp.2016.04.002. Epub 2016 Apr 14"