| Title: | Metabolomics in chemical ecology |
| Address: | "Friedrich Schiller University, Institute of Inorganic and Analytical Chemistry, Lessingstr. 8, D-07743 Jena, Germany. Georg.Pohnert@uni-jena.de" |
| ISSN/ISBN: | 1460-4752 (Electronic) 0265-0568 (Linking) |
| Abstract: | "Chemical ecology elucidates the nature and role of natural products as mediators of organismal interactions. The emerging techniques that can be summarized under the concept of metabolomics provide new opportunities to study such environmentally relevant signaling molecules. Especially comparative tools in metabolomics enable the identification of compounds that are regulated during interaction situations and that might play a role as e.g. pheromones, allelochemicals or in induced and activated defenses. This approach helps overcoming limitations of traditional bioassay-guided structure elucidation approaches. But the power of metabolomics is not limited to the comparison of metabolic profiles of interacting partners. Especially the link to other -omics techniques helps to unravel not only the compounds in question but the entire biosynthetic and genetic re-wiring, required for an ecological response. This review comprehensively highlights successful applications of metabolomics in chemical ecology and discusses existing limitations of these novel techniques. It focuses on recent developments in comparative metabolomics and discusses the use of metabolomics in the systems biology of organismal interactions. It also outlines the potential of large metabolomics initiatives for model organisms in the field of chemical ecology" |
| Keywords: | Animals *Ecology Host-Pathogen Interactions/physiology Marine Biology Metabolomics/*trends Molecular Structure Nematoda/physiology Plants; |
| Notes: | "MedlineKuhlisch, Constanze Pohnert, Georg eng Research Support, Non-U.S. Gov't Review England 2015/05/01 Nat Prod Rep. 2015 Jul; 32(7):937-55. doi: 10.1039/c5np00003c" |
