| Title: | Chemical composition and biological activities of extracts and essential oil of Boswellia dalzielii leaves |
| Author(s): | Kohoude MJ; Gbaguidi F; Agbani P; Ayedoun MA; Cazaux S; Bouajila J; |
| Address: | "a Laboratoire des IMRCP UMR CNRS 5623, Faculte de pharmacie de Toulouse, Universite de Toulouse , Toulouse , France. b Laboratoire de Pharmacognosie, Center Beninois de la Recherche Scientifique et Technique (CBRST), Universite Paul-Sabatier , Porto-Novo , Benin. c Laboratory of Physical Organic Chemistry and Synthesis (LaCOPS), Faculty of Technical Sciences, University of Abomey Calavi , Contonou , Benin" |
| DOI: | 10.1080/13880209.2016.1226356 |
| ISSN/ISBN: | 1744-5116 (Electronic) 1388-0209 (Print) 1388-0209 (Linking) |
| Abstract: | "CONTEXT: Boswellia dalzielii Hutch. (Burseraceae) is an aromatic plant. The leaves are used for beverage flavouring. OBJECTIVE: This study investigates the chemical composition and biological activities of various extracts. MATERIALS AND METHODS: The essential oil was prepared via hydrodistillation. Identification and quantification were realized via GC-MS and GC-FID. Consecutive extractions (cyclohexane, dichloromethane, ethyl acetate and methanol) were carried out and various chemical groups (phenolics, flavonoids, tannins, antocyanins and sugar) were quantified. The volatile compounds of organic extracts were identified before and after derivatization. Antioxidant, antihyperuricemia, anti-Alzheimer, anti-inflammatory and anticancer activities were evaluated. RESULTS: In the essential oil, 50 compounds were identified, including 3-carene (27.72%) and alpha-pinene (15.18%). 2,5-Dihydroxy acetophenone and beta-d-xylopyranose were identified in the methanol extract. Higher phenolic (315.97 g GAE/kg dry mass) and flavonoid (37.19 g QE/kg dry mass) contents were observed in the methanol extract. The methanol extract has presented remarkable IC(50 )=( )6.10 mg/L for antiDPPH, 35.10 mg/L for antixanthine oxidase and 28.01 mg/L for anti-5-lipoxygenase. For acetylcholinesterase inhibition, the best IC(50) (76.20 and 67.10 mg/L) were observed, respectively, with an ethyl acetate extract and the essential oil. At 50 mg/L, the dichloromethane extract inhibited OVCAR-3 cell lines by 65.10%, while cyclohexane extract inhibited IGROV-1 cell lines by 92.60%. DISCUSSION AND CONCLUSION: Biological activities were fully correlated with the chemical groups of the extracts. The ethyl acetate and methanol extracts could be considered as potential alternatives for use in dietary supplements for the prevention or treatment of diseases because of these extracts natural antioxidant, antihyperuricemic and anti-inflammatory activities" |
| Keywords: | Alzheimer Disease/drug therapy/enzymology Anti-Inflammatory Agents/isolation & purification/*pharmacology Antineoplastic Agents/isolation & purification/*pharmacology Antioxidants/isolation & purification/*pharmacology Biphenyl Compounds/chemistry Boswell; |
| Notes: | "MedlineKohoude, Mideko Justin Gbaguidi, Fernand Agbani, Pierre Ayedoun, Marc-Abel Cazaux, Sylvie Bouajila, Jalloul eng England 2016/09/22 Pharm Biol. 2017 Dec; 55(1):33-42. doi: 10.1080/13880209.2016.1226356. Epub 2016 Sep 21" |
