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J Exp Biol

Title:		5-Hydroxy-tryptamine modulates pheromone-evoked local field potentials in the macroglomerular complex of the sphinx moth Manduca sexta
Author(s):		Kloppenburg P; Heinbockel T;
Address:		"Arizona Research Laboratories, Division of Neurobiology, University of Arizona, Gould-Simpson Building, Tucson, AZ 85721, USA. pk29@cornell.edu"
Journal Title:		J Exp Biol
Year:		2000
Volume:		203
Issue:		Pt 11
Page Number:		1701 - 1709
DOI:		10.1242/jeb.203.11.1701
ISSN/ISBN:		0022-0949 (Print) 0022-0949 (Linking)
Abstract:		"Extra- and intracellular recordings from an intact brain preparation were used to study the effects of 5-hydroxytryptamine (5-HT or serotonin) on projection neurons in the sexually dimorphic macroglomerular complex (MGC) in the antennal lobe of the male moth Manduca sexta. The MGC is a group of three identified glomeruli specialized for synaptic processing of primary afferent information about the multi-component sex pheromone of the female. We investigated the modulatory effects of 5-HT on pheromone-evoked local field potentials in the MGC. The magnitude and duration of these potentials, which are thought to be generated by a population of pheromone-sensitive projection neurons of the MGC, were increased by 5-HT. Using intracellular recordings from the neurites of individual MGC projection neurons, we found that 5-HT increased the number of action potentials in response to pheromonal stimulation. These findings correlate well with earlier experiments that used other recording techniques. Our results are further evidence that 5-HT modulates a population of pheromone-sensitive MGC projection neurons that relay information about the pheromonal stimulus from the MGC to higher-order centers in the protocerebrum and are therefore pivotal for mate-finding and odor-guided behavior"
Keywords:		Animals Evoked Potentials/drug effects Female Male Manduca/drug effects/*physiology Nervous System/drug effects Neurons/drug effects/*physiology Pheromones/*pharmacology Serotonin/*pharmacology;
Notes:		"MedlineKloppenburg, P Heinbockel, T eng AI-23253/AI/NIAID NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. England 2000/05/11 J Exp Biol. 2000 Jun; 203(Pt 11):1701-9. doi: 10.1242/jeb.203.11.1701"