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Int J Hyg Environ Health

Title:		"Effect of exposure to volatile organic compounds on plasma levels of neuropeptides, nerve growth factor and histamine in patients with self-reported multiple chemical sensitivity"
Author(s):		Kimata H;
Address:		"Department of Allergy, Ujitakeda Hospital, 24-1, Umonji, Uji, Uji-City, Kyoto Prefecture, 611-0021, Japan. unitikah@m12.alphanet.ne.jp"
Journal Title:		Int J Hyg Environ Health
Year:		2004
Volume:		207
Issue:		2
Page Number:		159 - 163
DOI:		10.1078/1438-4639-00262
ISSN/ISBN:		1438-4639 (Print) 1438-4639 (Linking)
Abstract:		"Plasma levels of substance P, vasoactive intestinal peptide and nerve growth factor, but not histamine, were elevated in patients with self-reported multiple chemical sensitivity (sMCS). Exposure to volatile organic compounds (VOC) increased plasma levels of all parameters in these patients, while it had no effect in normal subjects or patients with atopic eczema/dermatitis syndrome (AEDS). Exposure to VOC also enhanced skin wheal responses induced by histamine in patients with sMCS, while it failed to do so in normal or AEDS subjects. These results indicate that exposure to VOC may enhance neurogenic inflammation with concomitant enhancement of histamine-induced responses"
Keywords:		"Adult *Environmental Exposure Female Histamine/*blood Humans Inflammation Male Multiple Chemical Sensitivity/*physiopathology Nerve Growth Factor/*blood Neuropeptides/*blood Organic Chemicals/toxicity Stress, Psychological Volatilization;"
Notes:		"MedlineKimata, Hajime eng Germany 2004/03/23 Int J Hyg Environ Health. 2004 Feb; 207(2):159-63. doi: 10.1078/1438-4639-00262"