| Title: | Association between environmental pollutants and the FSH/AMH ratio as a marker of ovarian reserve |
| Author(s): | Kim Y; Lee E; Song JY; Kim Y; Lee S; |
| Address: | "Department of Public Health, Korea University Graduate School, Seoul 02841, Republic of Korea. Department of Preventive Medicine, Korea University College of Medicine, Seoul 02841, Republic of Korea. Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul 02841, Republic of Korea. Department of Biomedical Sciences, Korea University Graduate School, Seoul 02841, Republic of Korea" |
| Journal Title: | Environ Anal Health Toxicol |
| ISSN/ISBN: | 2671-9525 (Electronic) 2671-9525 (Linking) |
| Abstract: | "The ovarian function decreases with age, and various markers, such as follicle stimulating hormone, inhibin B, antral follicle count, and anti-Mullerian hormone, are used for its evaluation. Recently, exposure to various environmental pollutants in daily life has been reported as an important cause of ovarian function decline. Therefore, the present study aimed to confirm the effect of environmental pollutants on the relationship between age and decline in ovarian function. The exposure levels of 16 environmental pollutants were evaluated in women aged 26-40 years, and the AMH levels and FSH/AMH ratios were used as markers for the decline of ovarian function. The participants were divided into two groups: low-level or high-level for each environmental pollutant if their exposure level was below or above the median respectively. The slope of the decrease or increase in the AMH level and FSH/AMH ratio of each group with age was evaluated. The FSH/AMH ratio better presented the difference in the rate of change with age in each group than did AMH alone. In particular, the rate of change in the FSH/AMH ratio increased 5.2 and 3.7 times (p<0.05) in the group exposed to high levels of the volatile organic compound metabolite, trans, trans-muconic acid and the polycyclic aromatic hydrocarbons metabolite, 2-hydroxynaphthalene, respectively, than in the low-level exposure groups for those metabolites. This study confirmed that environmental pollutants influenced the rate of change in the FSH/AMH ratio with age. Further studies on larger populations are necessary in the future" |
| Keywords: | Anti-Mullerian Hormone Environmental pollutants FSH/AMH ratio; |
| Notes: | "PubMed-not-MEDLINEKim, Yanghee Lee, Eunil Song, Jae Yun Kim, YunJeong Lee, Seoeun eng Korea Environment Industry & Technology Institute/ 2016001360007/Ministry of Environment/ Korea (South) 2023/03/15 Environ Anal Health Toxicol. 2022 Dec; 37(4):e2022029-0. doi: 10.5620/eaht.2022029. Epub 2022 Oct 11" |
