| Title: | Characteristic molecular signatures of early exposure to volatile organic compounds in rat liver |
| Author(s): | Kim JK; Eun JW; Bae HJ; Shen Q; Park SJ; Kim HS; Park S; Ahn YM; Park WS; Lee JY; Nam SW; |
| Address: | "Department of Pathology, College of Medicine, The Catholic University of Korea , Seoul , Republic of Korea" |
| DOI: | 10.3109/1354750X.2013.847121 |
| ISSN/ISBN: | 1366-5804 (Electronic) 1354-750X (Linking) |
| Abstract: | "OBJECTIVE: Investigation on whether the characteristic molecular signatures can discriminate individual volatile organic compounds (VOCs) and provide predictive markers for the detection of VOC exposure. METHODS: Transcriptomic analysis of liver tissues was performed 48 h after the single oral administration of three VOCs doses at LD25 or LD5 values, to Sprague-Dawley. RESULTS: Combination analysis of different multi-classifications suggested that 145 genes predicted VOC exposure. Additionally, Gene Set Enrichment Analysis of genes deregulated by VOCs revealed that T cell prolymphatic leukemia signaling was inactivated in all VOCs. CONCLUSIONS: These molecular markers could be widely implemented to assess and predict environmental exposure to VOCs" |
| Keywords: | "Animals Liver/chemistry/*drug effects Models, Biological Rats Rats, Sprague-Dawley *Transcriptome Volatile Organic Compounds/analysis/*toxicity;" |
| Notes: | "MedlineKim, Jeong Kyu Eun, Jung Woo Bae, Hyun Jin Shen, Qingyu Park, Se Jin Kim, Hyung Seok Park, Soha Ahn, Young Min Park, Won Sang Lee, Jung Young Nam, Suk Woo eng Research Support, Non-U.S. Gov't England 2013/10/23 Biomarkers. 2013 Dec; 18(8):706-15. doi: 10.3109/1354750X.2013.847121. Epub 2013 Oct 21" |
