| Title: | "Breathomics: Review of Sample Collection and Analysis, Data Modeling and Clinical Applications" |
| Author(s): | Khoubnasabjafari M; Mogaddam MRA; Rahimpour E; Soleymani J; Saei AA; Jouyban A; |
| Address: | "Tuberculosis and Lung Diseases Research Center and Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Liver and Gastrointestinal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry I, Karolinska Institutet, Stockholm, Sweden. School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran" |
| DOI: | 10.1080/10408347.2021.1889961 |
| ISSN/ISBN: | 1547-6510 (Electronic) 1040-8347 (Linking) |
| Abstract: | "Metabolomics research is rapidly gaining momentum in disease diagnosis, on top of other Omics technologies. Breathomics, as a branch of metabolomics is developing in various frontiers, for early and noninvasive monitoring of disease. This review starts with a brief introduction to metabolomics and breathomics. A number of important technical issues in exhaled breath collection and factors affecting the sampling procedures are presented. We review the recent progress in metabolomics approaches and a summary of their applications on the respiratory and non-respiratory diseases investigated by breath analysis. Recent reports on breathomics studies retrieved from Scopus and Pubmed were reviewed in this work. We conclude that analyzing breath metabolites (both volatile and nonvolatile) is valuable in disease diagnoses, and therefore believe that breathomics will turn into a promising noninvasive discipline in biomarker discovery and early disease detection in personalized medicine. The problem of wide variations in the reported metabolite concentrations from breathomics studies should be tackled by developing more accurate analytical methods and sophisticated numerical analytical alogorithms" |
| Keywords: | Biomarkers/analysis Breath Tests/methods *Data Analysis Exhalation Metabolomics/methods *Volatile Organic Compounds/analysis Biomarker exhaled breath metabolomics personalized medicine; |
| Notes: | "MedlineKhoubnasabjafari, Maryam Mogaddam, Mohamad Reza Afshar Rahimpour, Elaheh Soleymani, Jafar Saei, Amir Ata Jouyban, Abolghasem eng Review 2021/03/12 Crit Rev Anal Chem. 2022; 52(7):1461-1487. doi: 10.1080/10408347.2021.1889961. Epub 2021 Mar 11" |
