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Environ Sci Pollut Res Int

Title:		"Characterization of US population levels of urinary methylcarbamoyl mercapturic acid, a metabolite of N,N-dimethylformamide and methyl isocyanate, in the National Health and Nutrition Examination Survey (NHANES) 2005-2006 and 2011-2016"
Author(s):		Kenwood BM; Bagchi P; Zhang L; Zhu W; Chambers DM; Blount BC; De Jesus VR;
Address:		"Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA. mnv9@cdc.gov. Emory Integrated Proteomics Core, Emory University, Atlanta, GA, 30322, USA. Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA"
Journal Title:		Environ Sci Pollut Res Int
Year:		2021
Volume:		20210104
Issue:		13
Page Number:		16781 - 16791
DOI:		10.1007/s11356-020-12135-7
ISSN/ISBN:		1614-7499 (Electronic) 0944-1344 (Print) 0944-1344 (Linking)
Abstract:		"Methylcarbamoyl mercapturic acid (MCAMA, N-acetyl-S-(N-methylcarbamoyl)-L-cysteine) is a urinary metabolite of N,N-dimethylformamide and methyl isocyanate, which are volatile organic compounds that are harmful to humans. N,N-dimethylformamide exposure causes liver damage, and methyl isocyanate inhalation damages the lining of the respiratory tract, which can increase risk of chronic obstructive pulmonary disease and asthma. This study characterizes urinary MCAMA levels in the US population and explores associations of MCAMA concentrations with select demographic and environmental factors. We used liquid chromatography tandem mass spectrometry to measure MCAMA in urine collected from study participants >/= 12 years old (N = 8272) as part of the National Health and Nutrition Examination Survey 2005-2006 and 2011-2016. We produced multiple regression models with MCAMA concentrations as the dependent variable and sex, age, fasting time, race/ethnicity, diet, and cigarette smoking as independent variables. Cigarette smokers and nonsmokers had median urinary MCAMA concentrations of 517 mug/g creatinine and 127 mug/g creatinine, respectively. Sample-weighted multiple regression analysis showed that MCAMA was positively associated with serum cotinine (p < 0.0001). Compared to non-exposed participants (serum cotinine 0.015- 20 cigarettes per day was associated with 416% higher MCAMA (p < 0.0001). These findings underscore the strong association of tobacco smoke exposure with urinary MCAMA biomarker levels"
Keywords:		"Acetylcysteine Biomarkers Child Cotinine *Dimethylformamide Humans Isocyanates Nutrition Surveys *Tobacco Smoke Pollution/analysis Methyl isocyanate Methylcarbamoyl mercapturic acid N, N-Dimethylformamide N-acetyl-S-(N-methylcarbamoyl)-L-cysteine Tobacco s;"
Notes:		"MedlineKenwood, Brandon M Bagchi, Pritha Zhang, Luyu Zhu, Wanzhe Chambers, David M Blount, Benjamin C De Jesus, Victor R eng CC999999/ImCDC/Intramural CDC HHS/ Germany 2021/01/06 Environ Sci Pollut Res Int. 2021 Apr; 28(13):16781-16791. doi: 10.1007/s11356-020-12135-7. Epub 2021 Jan 4"