« Previous AbstractAsymmetric organic synthesis with catalytic antibodies    Next AbstractAccumulation of properly folded human type III procollagen molecules in specific intracellular membranous compartments in the yeast Pichia pastoris »

Nicotine Tob Res

Title:		"Characterization of Volatile Organic Compound Metabolites in Cigarette Smokers, Electronic Nicotine Device Users, Dual Users, and Nonusers of Tobacco"
Author(s):		Keith RJ; Fetterman JL; Orimoloye OA; Dardari Z; Lorkiewicz PK; Hamburg NM; DeFilippis AP; Blaha MJ; Bhatnagar A;
Address:		"American Heart Association Tobacco, Regulation and Addiction Center, University of Louisville School of Medicine, Louisville, KY. American Heart Association Tobacco, Regulation and Addiction Center, Vascular Biology Section, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA. American Heart Association Tobacco, Regulation and Addiction Center, Ciccarone Center for the Prevention of Heart Disease, John Hopkins Hospital, Baltimore, MD"
Journal Title:		Nicotine Tob Res
Year:		2020
Volume:		22
Issue:		2
Page Number:		264 - 272
DOI:		10.1093/ntr/ntz021
ISSN/ISBN:		1469-994X (Electronic) 1462-2203 (Print) 1462-2203 (Linking)
Abstract:		"INTRODUCTION: Limited research exists about the possible cardiovascular effects of electronic nicotine delivery systems (ENDS). We therefore sought to compare exposure to known or potentially cardiotoxic volatile organic compounds (VOCs) in ENDS users, smokers, and dual users. METHODS: A total of 371 individuals from the Cardiovascular Injury due to Tobacco Use study, a cross-sectional study of healthy participants aged 21-45 years, were categorized as nonusers of tobacco (n = 87), sole ENDS users (n = 17), cigarette smokers (n = 237), and dual users (n = 30) based on 30-day self-reported tobacco product use patterns. Participants provided urine samples for VOC and nicotine metabolite measurement. We assessed associations between tobacco product use and VOC metabolite measures using multivariable-adjusted linear regression models. RESULTS: Mean (SD) age of the population was 32 (+/-6.8) years, 55% men. Mean urinary cotinine level in nonusers of tobacco was 2.6 ng/mg creatinine, whereas cotinine levels were similar across all tobacco product use categories (851.6-910.9 ng/mg creatinine). In multivariable-adjusted models, sole ENDS users had higher levels of metabolites of acrolein, acrylamide, acrylonitrile, and xylene compared with nonusers of tobacco, but lower levels of most VOC metabolites compared with cigarette smokers or dual users. In direct comparison of cigarettes smokers and dual users, we found lower levels of metabolites of styrene and xylene in dual users. CONCLUSION: Although sole ENDS use may be associated with lower VOC exposure compared to cigarette smoking, further study is required to determine the potential health effects of the higher levels of certain reactive aldehydes, including acrolein, in ENDS users compared with nonusers of tobacco. IMPLICATIONS: ENDS use in conjunction with other tobacco products may not significantly reduce exposure to VOC, but sole use does generally reduce some VOC exposure and warrants more in-depth studies"
Keywords:		Adult Biomarkers/metabolism/urine Cigarette Smoking/*metabolism/urine Cohort Studies Cotinine/metabolism/urine Cross-Sectional Studies *Electronic Nicotine Delivery Systems Female Humans Male Middle Aged Nicotine/metabolism/urine *Non-Smokers *Smokers Vap;
Notes:		"MedlineKeith, Rachel J Fetterman, Jessica L Orimoloye, Olusola A Dardari, Zeina Lorkiewicz, Pawel K Hamburg, Naomi M DeFilippis, Andrew P Blaha, Michael J Bhatnagar, Aruni eng P42 ES023716/ES/NIEHS NIH HHS/ P50 HL120163/HL/NHLBI NIH HHS/ Research Support, N.I.H., Extramural England 2019/02/14 Nicotine Tob Res. 2020 Feb 6; 22(2):264-272. doi: 10.1093/ntr/ntz021"