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J Comp Physiol A Neuroethol Sens Neural Behav Physiol

Title:		Kinetics of olfactory responses might largely depend on the odorant-receptor interaction and the odorant deactivation postulated for flux detectors
Author(s):		Kaissling KE;
Address:		"Max-Planck-Institut fuer Verhaltensphysiologie/Ornithologie, Seewiesen, 82319, Starnberg, Germany, kaissling@orn.mpg.de"
Journal Title:		J Comp Physiol A Neuroethol Sens Neural Behav Physiol
Year:		2013
Volume:		20130407
Issue:		11
Page Number:		879 - 896
DOI:		10.1007/s00359-013-0812-z
ISSN/ISBN:		1432-1351 (Electronic) 0340-7594 (Linking)
Abstract:		"Experimental data together with modeling of pheromone perireceptor and receptor events in moths (Bombyx mori, Antheraea polyphemus) suggest that the kinetics of olfactory receptor potentials largely depend on the association of the odorant with the neuronal receptor molecules and the deactivation of the odorant accumulated around the receptor neuron. The first process could be responsible for the reaction times (mean about 400 ms) of the nerve impulses at threshold. The second process has been postulated for flux detectors such as olfactory sensilla of moths. The odorant deactivation could involve a modification of the pheromone-binding protein (PBP) that 'locks' the pheromone inside the inner binding cavity of the protein. The model combines seemingly contradictory functions of the PBP such as pheromone transport, protection of the pheromone from enzymatic degradation, pheromone deactivation, and pheromone-receptor interaction. Model calculations reveal a density of at least 6,000 receptor molecules per microm(2) of neuronal membrane. The volatile decanoyl-thio-1,1,1-trifluoropropanone specifically blocks pheromone receptor neurons, probably when bound to the PBP and by competitive binding to the receptor molecules. The shallow dose-response curve of the receptor potential and altered response properties observed with pheromone derivatives or after adaptation may indicate shortened opening of ion channels"
Keywords:		"Animals Kinetics *Models, Biological Moths Olfactory Receptor Neurons/*physiology Receptors, Odorant/*metabolism Signal Transduction/*physiology Smell/*physiology;"
Notes:		"MedlineKaissling, Karl-Ernst eng Review Germany 2013/04/09 J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2013 Nov; 199(11):879-96. doi: 10.1007/s00359-013-0812-z. Epub 2013 Apr 7"