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J Insect Physiol

Title:		"Flubendiamide, the first phthalic acid diamide insecticide, impairs neuronal calcium signalling in the honey bee's antennae"
Author(s):		Kadala A; Charreton M; Collet C;
Address:		"INRAE, UR406 Abeilles et Environnement, 84914 Avignon, France; UMT PRADE, Protection des Abeilles dans l'Environnement, 84914 Avignon, France. INRAE, UR406 Abeilles et Environnement, 84914 Avignon, France; UMT PRADE, Protection des Abeilles dans l'Environnement, 84914 Avignon, France. Electronic address: claude.collet@inrae.fr"
Journal Title:		J Insect Physiol
Year:		2020
Volume:		20200703
Issue:
Page Number:		104086 -
DOI:		10.1016/j.jinsphys.2020.104086
ISSN/ISBN:		1879-1611 (Electronic) 0022-1910 (Linking)
Abstract:		"Calcium is an important intracellular second messenger involved in several processes such as the transduction of odour signals and neuronal excitability. Despite this critical role, relatively little information is available with respect to the impact of insecticides on the dynamics of intracellular calcium homeostasis in olfactory neurons. For the first time here, physiological stimuli (depolarizing current or pheromone) were shown to elicit calcium transients in peripheral neurons from the honey bee antenna. In addition, neurotoxic xenobiotics (the first synthetic phthalic diamide insecticide flubendiamide or botanical alkaloids ryanodine and caffeine) do interfere with normal calcium homeostasis. Our in vitro experiments show that these three xenobiotics can induce sustained abnormal calcium transients in antennal neurons. The present results provide a new insight into the toxicity of diamides, showing that flubendiamide drastically impairs calcium homeostasis in antennal neurons. We propose that a calcium imaging assay should provide an efficient tool dedicated to the modern assessment strategies of insecticides toxicity"
Keywords:		Animals Arthropod Antennae/*drug effects/physiology Benzamides/*adverse effects Calcium/*metabolism Insecticides/*adverse effects Neurons/*drug effects/physiology Signal Transduction/*drug effects Sulfones/*adverse effects Caffeine Calcium Flubendiamide H;
Notes:		"MedlineKadala, Aklesso Charreton, Mercedes Collet, Claude eng Research Support, Non-U.S. Gov't England 2020/07/07 J Insect Physiol. 2020 Aug-Sep; 125:104086. doi: 10.1016/j.jinsphys.2020.104086. Epub 2020 Jul 3"