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Org Biomol Chem

Title:		The enantioselective total synthesis of nemotin
Author(s):		Jian YJ; Wu Y;
Address:		"State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai, 200032, China"
Journal Title:		Org Biomol Chem
Year:		2010
Volume:		20100104
Issue:		4
Page Number:		811 - 821
DOI:		10.1039/b923123d
ISSN/ISBN:		1477-0539 (Electronic) 1477-0520 (Linking)
Abstract:		"The allene-diyne natural product nemotin was synthesized for the first time through an enantioselective route with the stereogenic center at the lactone moiety derived from l-glutamic acid and the allene axis constructed from the corresponding propargylic tosylate, and the absolute configuration was thus established as (4S,5aS)"
Keywords:		"Alkadienes/*chemical synthesis Antineoplastic Agents, Phytogenic/chemical synthesis Catalysis Cyclization Glutamic Acid/*chemistry Kv1.3 Potassium Channel Lactones/*chemistry Models, Chemical Sex Attractants/chemical synthesis/chemistry *Stereoisomerism S;"
Notes:		"MedlineJian, Ya-Jun Wu, Yikang eng Research Support, Non-U.S. Gov't England 2010/02/06 Org Biomol Chem. 2010 Feb 21; 8(4):811-21. doi: 10.1039/b923123d. Epub 2010 Jan 4"