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Metabolites

Title:		Critical Review of Volatile Organic Compound Analysis in Breath and In Vitro Cell Culture for Detection of Lung Cancer
Author(s):		Jia Z; Patra A; Kutty VK; Venkatesan T;
Address:		"NUSNNI-Nanocore, National University of Singapore, Singapore 117411, Singapore. nnijz@nus.edu.sg. NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117456, Singapore. nnijz@nus.edu.sg. NUSNNI-Nanocore, National University of Singapore, Singapore 117411, Singapore. abhijeet@nus.edu.sg. NUSNNI-Nanocore, National University of Singapore, Singapore 117411, Singapore. viknish@nus.edu.sg. NUSNNI-Nanocore, National University of Singapore, Singapore 117411, Singapore. venky@nus.edu.sg. NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 117456, Singapore. venky@nus.edu.sg. Department of Electrical Engineering, National University of Singapore, Singapore 117583, Singapore. venky@nus.edu.sg. Department of Materials Science and Engineering, National University of Singapore, Singapore 117574, Singapore. venky@nus.edu.sg. Department of Physics, National University of Singapore, Singapore 117581, Singapore. venky@nus.edu.sg"
Journal Title:		Metabolites
Year:		2019
Volume:		20190318
Issue:		3
Page Number:		-
DOI:		10.3390/metabo9030052
ISSN/ISBN:		2218-1989 (Print) 2218-1989 (Electronic) 2218-1989 (Linking)
Abstract:		"Breath analysis is a promising technique for lung cancer screening. Despite the rapid development of breathomics in the last four decades, no consistent, robust, and validated volatile organic compound (VOC) signature for lung cancer has been identified. This review summarizes the identified VOC biomarkers from both exhaled breath analysis and in vitro cultured lung cell lines. Both clinical and in vitro studies have produced inconsistent, and even contradictory, results. Methodological issues that lead to these inconsistencies are reviewed and discussed in detail. Recommendations on addressing specific issues for more accurate biomarker studies have also been made"
Keywords:		biomarker breath analysis in vitro study lung cancer volatile organic compound;
Notes:		"PubMed-not-MEDLINEJia, Zhunan Patra, Abhijeet Kutty, Viknish Krishnan Venkatesan, Thirumalai eng Review Switzerland 2019/03/21 Metabolites. 2019 Mar 18; 9(3):52. doi: 10.3390/metabo9030052"