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Endocrinology

Title:		Neural and Hormonal Control of Sexual Behavior
Author(s):		Jennings KJ; de Lecea L;
Address:		"Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California"
Journal Title:		Endocrinology
Year:		2020
Volume:		161
Issue:		10
Page Number:		-
DOI:		10.1210/endocr/bqaa150
ISSN/ISBN:		1945-7170 (Electronic) 0013-7227 (Print) 0013-7227 (Linking)
Abstract:		"Gonadal hormones contribute to the sexual differentiation of brain and behavior throughout the lifespan, from initial neural patterning to 'activation' of adult circuits. Sexual behavior is an ideal system in which to investigate the mechanisms underlying hormonal activation of neural circuits. Sexual behavior is a hormonally regulated, innate social behavior found across species. Although both sexes seek out and engage in sexual behavior, the specific actions involved in mating are sexually dimorphic. Thus, the neural circuits mediating sexual motivation and behavior in males and females are overlapping yet distinct. Furthermore, sexual behavior is strongly dependent on circulating gonadal hormones in both sexes. There has been significant recent progress on elucidating how gonadal hormones modulate physiological properties within sexual behavior circuits with consequences for behavior. Therefore, in this mini-review we review the neural circuits of male and female sexual motivation and behavior, from initial sensory detection of pheromones to the extended amygdala and on to medial hypothalamic nuclei and reward systems. We also discuss how gonadal hormones impact the physiology and functioning of each node within these circuits. By better understanding the myriad of ways in which gonadal hormones impact sexual behavior circuits, we can gain a richer and more complete appreciation for the neural substrates of complex behavior"
Keywords:		"Adult Animals Brain/*physiology Female Hormones/pharmacology/*physiology Humans Male Nerve Net/metabolism/physiology Sex Characteristics Sex Differentiation/drug effects/physiology Sexual Behavior/drug effects/*physiology/psychology Sexual Behavior, Anima;"
Notes:		"MedlineJennings, Kimberly J de Lecea, Luis eng F32 HD095597/HD/NICHD NIH HHS/ Research Support, N.I.H., Extramural Review 2020/08/28 Endocrinology. 2020 Oct 1; 161(10):bqaa150. doi: 10.1210/endocr/bqaa150"