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Cancers (Basel)

Title:		Chemoresistive Nanosensors Employed to Detect Blood Tumor Markers in Patients Affected by Colorectal Cancer in a One-Year Follow Up
Author(s):		Astolfi M; Rispoli G; Anania G; Zonta G; Malagu C;
Address:		"Department of Physics and Earth Sciences, University of Ferrara, 44122 Ferrara, Italy. SCENT S.r.l., Via Quadrifoglio 11, 44124 Ferrara, Italy. Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy. Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy"
Journal Title:		Cancers (Basel)
Year:		2023
Volume:		20230316
Issue:		6
Page Number:		-
DOI:		10.3390/cancers15061797
ISSN/ISBN:		2072-6694 (Print) 2072-6694 (Electronic) 2072-6694 (Linking)
Abstract:		"Colorectal cancer (CRC) represents 10% of the annual tumor diagnosis and deaths occurring worldwide. Given the lack of specific symptoms, which could determine a late diagnosis, the research for specific CRC biomarkers and for innovative low-invasive methods to detect them is crucial. Therefore, on the basis of previously published results, some volatile organic compounds (VOCs), detectable through gas sensors, resulted in particularly promising CRC biomarkers, making these sensors suitable candidates to be employed in CRC screening devices. A new device was employed here to analyze the exhalations of blood samples collected from CRC-affected patients at different stages of their pre- and post-surgery therapeutic path, in order to assess the sensor's capability for discriminating among these samples. The stages considered were: the same day of the surgical treatment (T1); before the hospital discharge (T2); after one month and after 10-12 months from surgery (T3 and T4, respectively). This device, equipped with four different sensors based on different metal-oxide mixtures, enabled a distinction between T1 and T4 with a sensitivity and specificity of 93% and 82%, respectively, making it suitable for clinical follow-up protocols, patient health status monitoring and to detect possible post-treatment relapses"
Keywords:		VOCs blood chemoresistivity colorectal cancer follow-up gas sensor nanotechnology preventive screening;
Notes:		"PubMed-not-MEDLINEAstolfi, Michele Rispoli, Giorgio Anania, Gabriele Zonta, Giulia Malagu, Cesare eng Switzerland 2023/03/30 Cancers (Basel). 2023 Mar 16; 15(6):1797. doi: 10.3390/cancers15061797"