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Nanomedicine (Lond)

Title:		Impact of hemodialysis on exhaled volatile organic compounds in end-stage renal disease: a pilot study
Author(s):		Assady S; Marom O; Hemli M; Ionescu R; Jeries R; Tisch U; Abassi Z; Haick H;
Address:		"Department of Nephrology, Rambam Health Care Campus, Haifa 31096, Israel"
Journal Title:		Nanomedicine (Lond)
Year:		2014
Volume:		20130925
Issue:		7
Page Number:		1035 - 1045
DOI:		10.2217/nnm.13.85
ISSN/ISBN:		1748-6963 (Electronic) 1743-5889 (Linking)
Abstract:		"AIM: To demonstrate the feasibility of nanomaterial-based sensors for identifying patterns of exhaled volatile organic compound of end-stage renal disease (ESRD) and study the impact of hemodialysis (HD) on these patterns. PATIENTS & METHODS: Exhaled breath samples were collected from a group of 37 volunteers (26 ESRD HD patients; 11 healthy controls); a third of the samples were randomly blinded for determining the sensitivity/specificity of the method. Discriminant function analysis was used to build a model for discriminating ESRD patients and healthy controls (classification accuracy for blind samples: 80%), based on the signals of the nanomaterial sensors. RESULTS & CONCLUSION: The breath pattern of the ESRD patients approached the healthy pattern during the HD treatment, without reaching it completely. Gas chromatography/mass spectrometry identified four volatile organic compounds as potential ESRD biomarkers. Although this pilot study has yielded encouraging results, additional large-scale clinical studies are required to develop a fast, noninvasive breath test for monitoring HD adequacy in real time"
Keywords:		"Adult Aged Aged, 80 and over Breath Tests Female Gas Chromatography-Mass Spectrometry Humans Kidney Failure, Chronic/*metabolism Male Middle Aged *Renal Dialysis Volatile Organic Compounds/*analysis breath test carbon nanotube dialysis adequacy end-stage;"
Notes:		"MedlineAssady, Suheir Marom, Ophir Hemli, Matan Ionescu, Radu Jeries, Raneen Tisch, Ulrike Abassi, Zaid Haick, Hossam eng Research Support, Non-U.S. Gov't England 2013/09/27 Nanomedicine (Lond). 2014 May; 9(7):1035-45. doi: 10.2217/nnm.13.85. Epub 2013 Sep 25"