| Title: | Current application and potential use of GC?ª+x?ª+GC in the pharmaceutical and biomedical field |
| Author(s): | Aspromonte J; Wolfs K; Adams E; |
| Address: | "KU Leuven - University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, Herestraat 49, O&N2, PB 923, 3000 Leuven, Belgium. KU Leuven - University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, Herestraat 49, O&N2, PB 923, 3000 Leuven, Belgium. Electronic address: Erwin.Adams@kuleuven.be" |
| DOI: | 10.1016/j.jpba.2019.112817 |
| ISSN/ISBN: | 1873-264X (Electronic) 0731-7085 (Linking) |
| Abstract: | "The analysis of volatile samples is mostly performed by GC. However, its separation power may not be enough for some complex samples. Comprehensive gas chromatography (GC?ª+x?ª+GC) increases the separation power by means of a second separation dimension. Parallel to the great technological advances realised since the early stages of the technique, considerable applications in different fields have emerged. Nonetheless, it is still often seen as a novelty, thus being rarely considered a fully established technique for routine analysis. In this article we review different recent applications of GC?ª+x?ª+GC in the pharmaceutical and biomedical field, highlighting the obtained results and advantages compared to other methods when possible. We aim to encourage researchers to embrace GC?ª+x?ª+GC as a possible alternative to improve their results by presenting its great application potential in this area" |
| Keywords: | "Biomedical Research/*methods Chemistry, Pharmaceutical/*methods Chromatography, Gas/*methods Volatile Organic Compounds/*analysis Bioanalytical Comprehensive multidimensional GC GCG__xG__GC Pharmaceutical;" |
| Notes: | "MedlineAspromonte, Juan Wolfs, Kris Adams, Erwin eng Review England 2019/08/27 J Pharm Biomed Anal. 2019 Nov 30; 176:112817. doi: 10.1016/j.jpba.2019.112817. Epub 2019 Aug 18" |
