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Sensors (Basel)

Title:		"Development of an Exhaled Breath Monitoring System with Semiconductive Gas Sensors, a Gas Condenser Unit, and Gas Chromatograph Columns"
Author(s):		Itoh T; Miwa T; Tsuruta A; Akamatsu T; Izu N; Shin W; Park J; Hida T; Eda T; Setoguchi Y;
Address:		"National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560, Japan. itoh-toshio@aist.go.jp. National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560, Japan. t-miwa@glc.shimadzu.co.jp. National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560, Japan. a.tsuruta@aist.go.jp. National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560, Japan. t-akamatsu@aist.go.jp. National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560, Japan. n-izu@aist.go.jp. National Institute of Advanced Industrial Science and Technology (AIST), Shimo-Shidami, Moriyama-ku, Nagoya 463-8560, Japan. w.shin@aist.go.jp. Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan. samasama75@gmail.com. Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan. 107974@aichi-cc.jp. Figaro Engineering Inc., 1-5-11 Sembanishi, Minoh, Osaka 562-8505, Japan. eda@figaro.co.jp. Figaro Engineering Inc., 1-5-11 Sembanishi, Minoh, Osaka 562-8505, Japan. setoguchi@figaro.co.jp"
Journal Title:		Sensors (Basel)
Year:		2016
Volume:		20161110
Issue:		11
Page Number:		-
DOI:		10.3390/s16111891
ISSN/ISBN:		1424-8220 (Electronic) 1424-8220 (Linking)
Abstract:		"Various volatile organic compounds (VOCs) in breath exhaled by patients with lung cancer, healthy controls, and patients with lung cancer who underwent surgery for resection of cancer were analyzed by gas condenser-equipped gas chromatography-mass spectrometry (GC/MS) for development of an exhaled breath monitoring prototype system involving metal oxide gas sensors, a gas condenser, and gas chromatography columns. The gas condenser-GC/MS analysis identified concentrations of 56 VOCs in the breath exhaled by the test population of 136 volunteers (107 patients with lung cancer and 29 controls), and selected four target VOCs, nonanal, acetoin, acetic acid, and propanoic acid, for use with the condenser, GC, and sensor-type prototype system. The prototype system analyzed exhaled breath samples from 101 volunteers (74 patients with lung cancer and 27 controls). The prototype system exhibited a level of performance similar to that of the gas condenser-GC/MS system for breath analysis"
Keywords:		Adult Biosensing Techniques/*methods Breath Tests/*methods Female Gas Chromatography-Mass Spectrometry/*methods Humans Lung Neoplasms/*metabolism Male Middle Aged Volatile Organic Compounds/analysis Gc condenser exhaled breath analysis gas condenser-equip;
Notes:		"MedlineItoh, Toshio Miwa, Toshio Tsuruta, Akihiro Akamatsu, Takafumi Izu, Noriya Shin, Woosuck Park, Jangchul Hida, Toyoaki Eda, Takeshi Setoguchi, Yasuhiro eng Switzerland 2016/11/12 Sensors (Basel). 2016 Nov 10; 16(11):1891. doi: 10.3390/s16111891"