| Title: | Detection of multiple sclerosis from exhaled breath using bilayers of polycyclic aromatic hydrocarbons and single-wall carbon nanotubes |
| Author(s): | Ionescu R; Broza Y; Shaltieli H; Sadeh D; Zilberman Y; Feng X; Glass-Marmor L; Lejbkowicz I; Mullen K; Miller A; Haick H; |
| Address: | "Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion, Israel Institute of Technology, Haifa 32000, Israel" |
| ISSN/ISBN: | 1948-7193 (Electronic) 1948-7193 (Print) 1948-7193 (Linking) |
| Abstract: | "A cross-reactive array of polycyclic aromatic hydrocarbons and single wall carbon nanotube bilayers was designed for the detection of volatile organic compounds (tentatively, hexanal and 5-methyl-undecane) that identify the presence of disease in the exhaled breath of patients with multiple sclerosis. The sensors showed excellent discrimination between hexanal, 5-methyl-undecane, and other confounding volatile organic compounds. Results obtained from a clinical study consisting of 51 volunteers showed that the sensors could discriminate between multiple sclerosis and healthy states from exhaled breath samples with 85.3% sensitivity, 70.6% specificity, and 80.4% accuracy. These results open new frontiers in the development of a fast, noninvasive, and inexpensive medical diagnostic tool for the detection and identification of multiple sclerosis. The results could serve also as a launching pad for the discrimination between different subphases or stages of multiple sclerosis as well as for the identification of multiple sclerosis patients who would respond well to immunotherapy" |
| Keywords: | "Breath Tests/instrumentation/*methods Exhalation/*physiology Female Follow-Up Studies Gas Chromatography-Mass Spectrometry/instrumentation/methods Humans Male Membranes, Artificial Multiple Sclerosis/*diagnosis/*metabolism *Nanotubes, Carbon/chemistry *Po;" |
| Notes: | "MedlineIonescu, Radu Broza, Yoav Shaltieli, Hila Sadeh, Dvir Zilberman, Yael Feng, Xinliang Glass-Marmor, Lea Lejbkowicz, Izabella Mullen, Klaus Miller, Ariel Haick, Hossam eng 2012/08/04 ACS Chem Neurosci. 2011 Dec 21; 2(12):687-93. doi: 10.1021/cn2000603. Epub 2011 Sep 22" |
