| Title: | Breathomics for the clinician: the use of volatile organic compounds in respiratory diseases |
| Author(s): | Ibrahim W; Carr L; Cordell R; Wilde MJ; Salman D; Monks PS; Thomas P; Brightling CE; Siddiqui S; Greening NJ; |
| Address: | "Department of Respiratory Sciences, University of Leicester, Leicester, UK. Institute for Lung Health, Leicester NIHR Biomedical Research Centre, Leicester, UK. School of Chemistry, University of Leicester, Leicester, UK. Department of Chemistry, Loughborough University, Loughborough, UK. Department of Respiratory Sciences, University of Leicester, Leicester, UK neil.greening@leicester.ac.uk" |
| DOI: | 10.1136/thoraxjnl-2020-215667 |
| ISSN/ISBN: | 1468-3296 (Electronic) 0040-6376 (Print) 0040-6376 (Linking) |
| Abstract: | "Exhaled breath analysis has the potential to provide valuable insight on the status of various metabolic pathways taking place in the lungs locally and other vital organs, via systemic circulation. For years, volatile organic compounds (VOCs) have been proposed as feasible alternative diagnostic and prognostic biomarkers for different respiratory pathologies.We reviewed the currently published literature on the discovery of exhaled breath VOCs and their utilisation in various respiratory diseasesKey barriers in the development of clinical breath tests include the lack of unified consensus for breath collection and analysis and the complexity of understanding the relationship between the exhaled VOCs and the underlying metabolic pathways. We present a comprehensive overview, in light of published literature and our experience from coordinating a national breathomics centre, of the progress made to date and some of the key challenges in the field and ways to overcome them. We particularly focus on the relevance of breathomics to clinicians and the valuable insights it adds to diagnostics and disease monitoring.Breathomics holds great promise and our findings merit further large-scale multicentre diagnostic studies using standardised protocols to help position this novel technology at the centre of respiratory disease diagnostics" |
| Keywords: | Biomarkers/metabolism Breath Tests/methods Exhalation Humans Lung/*metabolism Respiration Disorders/*metabolism Volatile Organic Compounds/*metabolism exhaled airway markers respiratory infection; |
| Notes: | "MedlineIbrahim, Wadah Carr, Liesl Cordell, Rebecca Wilde, Michael J Salman, Dahlia Monks, Paul S Thomas, Paul Brightling, Chris E Siddiqui, Salman Greening, Neil J eng MR/N005880/1/MRC_/Medical Research Council/United Kingdom PDF-2017-10-052/DH_/Department of Health/United Kingdom Research Support, Non-U.S. Gov't Review England 2021/01/09 Thorax. 2021 May; 76(5):514-521. doi: 10.1136/thoraxjnl-2020-215667. Epub 2021 Jan 7" |
