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Curr Opin Lipidol

Title:		CaaX converting enzymes
Author(s):		Ashby MN;
Address:		"Acacia Biosciences Inc., Richmond, CA 94806, USA. ashbym@acaciabio.com"
Journal Title:		Curr Opin Lipidol
Year:		1998
Volume:		9
Issue:		2
Page Number:		99 - 102
DOI:		10.1097/00041433-199804000-00004
ISSN/ISBN:		0957-9672 (Print) 0957-9672 (Linking)
Abstract:		"Proteins that contain a carboxyl-terminal CaaX motif undergo post-translational processing involving prenylation, endoproteolysis and methylesterification. Two yeast genes, AFC1 and RCE1, which are candidates for genes encoding CaaX converting enzymes, were recently identified. Rce1p is required for the full penetrance of the activated Ras2pval19 phenotype in yeast, indicating its possible utility as a new target in Ras-based malignancies. Advances in our current understanding of CaaX convertases and the functional importance of CaaX proteolysis are discussed"
Keywords:		Amino Acid Sequence *Arabidopsis Proteins Endopeptidases/*metabolism Fungal Proteins/*metabolism Hydrolysis Metalloendopeptidases Molecular Sequence Data Pheromones/chemistry/metabolism Plant Proteins/*metabolism Proprotein Convertases Protein Kinases/*me;
Notes:		"MedlineAshby, M N eng Review England 1998/04/29 Curr Opin Lipidol. 1998 Apr; 9(2):99-102. doi: 10.1097/00041433-199804000-00004"